EGFR在结直肠癌组织中的表达及其意义  

Signif icance of expression of epidermal growth factor receptor in colorectal cancer

作　　者：王丽[1] 余英豪[1] 刘伟[1] 王烈[2] 欧阳学农[3] 熊喜生[1] 

机构地区：[1]中国人民解放军南京军区福州总医院病理科,福建省福州市350025 [2]中国人民解放军南京军区福州总医院普外科,福建省福州市350025 [3]中国人民解放军南京军区福州总医院肿瘤科,福建省福州市350025

出　　处：《世界华人消化杂志》2011年第14期1483-1488,共6页World Chinese Journal of Digestology

基　　金：中国人民解放军南京军区科研基金资助项目;No.10MA107~~

摘　　要：目的:探讨结直肠癌患者肿瘤组织中表皮生长因子受体(epidermal growth factor,EGFR)过表达与临床病理特征及其预后的关系和意义.方法:收集2004-01/2010-04在中国人民解放军南京军区福州总医院手术切除的结直肠癌组织标本1228例,选择其中资料完整的病例1100例,采用EliVisionTMplus免疫组织化学方法检测癌组织EGFR的表达.通过Ridit分析和生存分析判断EGFR表达与各临床病理参数及其预后的关系.结果:1100例结直肠癌组织中EGFR阳性表达270例,表达率为24.55%.男性患者阳性表达率明显高于女性(27.04%vs19.01%,P=0.015),Ⅳ期、Ⅲ期肿瘤患者阳性表达率明显高于其他各期病例(40.74%vs30.58%,P<0.001),有淋巴结转移者EGFR阳性表达率明显高于无淋巴结转移者(32.10%vs19.09%,P<0.0001),有远处转移者EGFR阳性表达率明显高于无远处转移者(75.31%vs20.51%,P<0.0001);EGFR表达与患者年龄、肿瘤部位、肿瘤浸润深度、肿瘤分化程度等均无明显相关性,EGFR表达水平与患者总生存期无明显相关.结论:EGFR检测可以作为评估结直肠癌恶性生物学行为及其预后的参考指标.AIM：To detect the expression of epidermal growth factor receptor（EGFR） in colorectal cancer and to evaluate its relationship with clinicopathological parameters and prognosis in patients with colorectal cancer.METHODS：A total of 1 228 specimens were collected from patients with colorectal cancer who were treated at Fuzhou General Hospitalof Nanjing Military Command of Chinese PLA from January 2004 to April 2010.Immunohisto-chemistry was used to detect the expression of EGFR in 1 100 specimens taken from patients who had complete clinical data.Univariate and multivariate analyses were used to study the relationship of EGFR expression with clinicopath-ological parameters and prognosis in patients with colorectal cancer.RESULTS：The positive rate of EGFR expression was 24.55%（270/1 100）.Males had a significantly higher positive rate of EGFR expression than females（27.04% vs 19.01%,P = 0.015）.Patients with stages III and IV colorectal cancer had a significantly higher positive rate of EGFR expression than other patients（40.74% vs 30.58%,P0.001）.The positive rate of EGFR expression was significantly higher in patients with lymph node or distant metastasis than in those without metastasis（32.10% vs 19.09%,P0.0001）.EGFR expression was not significantly correlated with age,tumor location,invasion depth,differentiation,or overall survival.CONCLUSION：Detection of EGFR protein expression can be used to evaluate the malignant behavior and prognosis of colorectal cancer.

关 键 词：结直肠癌 表皮生长因子受体 免疫组织化学 病理学 TNM分期 预后 

分 类 号：R735.3[医药卫生—肿瘤]