功能性消化不良患者血浆ghrelin变化及其与胃排空的关系  

Plasma ghrelin and its Relationship with Gastric Emptying in Patients with Functional Dyspepsia

作　　者：苏菡[1] 朱一丹[1] 王新北[2] 刘广遐[1] 赵君宁[1] 梁国栋[1] 

机构地区：[1]江苏省老年医院消化内科,210024 [2]江苏省老年医院超声科,210024

出　　处：《胃肠病学》2011年第5期286-289,共4页Chinese Journal of Gastroenterology

摘　　要：背景:ghrelin已被证实具有促进胃肠动力的作用.而胃肠动力障碍是功能性消化不良(FD)的重要发病机制,目前关于ghrelin与FD关系的临床研究较少。目的:探讨FD患者血浆ghrelin变化及其与临床症状和胃排空的关系。方法:纳入40例FD患者,其中餐后不适综合征(PDS)25例.上腹痛综合征(EPS)15例,并以20名健康者作为对照:评估临床症状评分.以实时B超检测胃半排空时间(GET_(1/2)),ELISA法检测血浆酰基化ghrelin水平.并分析血浆酰基化ghrelin水平与临床症状评分和GET_(1/2)的关系。结果:与对照组相比,PDS组GET_(1/2)和血浆酰基化ghrelin水平明显升高(P<0.05),而EPS组无明显差异(P>0.05)。FD患者餐后饱胀与早饱症状评分之和与GET_(1/2)呈正相关(r=0.33,P=0.04).但与血浆酰基化ghrelin水平无关。PDS组和EPS组患者血浆酰基化ghrelin水平与临床症状评分均无关。PDS组患者血浆酰基化ghrelin水平与GET_(1/2)呈正相关(r=0.43,P=0.033),而EPS组中两者无关。结论:PDS患者血浆酰基化ghrelin水平明显升高,并与胃排空功能相关.提示ghrelin在FD的发生过程中发挥一定的作用。Background： ghrelin has been confirmed to play a role in accelerating gastrointestinal motility, and disorder of gastrointestinal motility is an important mechanism in the pathogenesis of functional dyspepsia （FD）. However, there are only few clinical studies on the relationship between ghrelin and FD. Aims： To investigate the alteration of plasma ghrelin and its relationship with clinical symptoms and gastric emptying in patients with FD. Methods： Forty FD patients including 25 postprandial distress syndrome （PDS） and 15 epigastric pain syndrome （EPS） were enrolled in the study. Twenty healthy subjects were served as controls. Clinical symptom score was assessed and gastric emptying half-time （GET1/2） was determined by real-time B-ultrasound. Plasma acylated ghrelin level was measured by ELISA and its relationship with clinical symptom score and GET1/2 was analyzed. Results： Compared with controls, GET1/2 and level of plasma aeylated ghrelin were significantly increased in PDS patients （P〈0.05）, however, no significant difference was observed between EPS patients and controls （P〉0.05）. Symptom score of postprandial fullness and early satiety in FD patients was positively correlated with GETIn （r=0.33, P=0.04）, but was not correlated with plasma acylated ghrelin level. No correlation was found between plasma acylated ghrelin level and score of clinical symptoms in both PDS and EPS patients. Plasma acylated ghrelin level was positively correlated with GET1/2 in patients with PDS （r=0.43, P=0.033）, but no significant correlation was found in EPS patients. Conclusions： Plasma acylated ghrelin level is significantly increased in PDS patients and is positively correlated with gastric emptying, which suggests that ghrelin may play some roles in the pathogenesis of FD.

关 键 词：消化不良 GHRELIN 胃肠激素类 胃排空 

分 类 号：R57[医药卫生—消化系统]