复方蜥蜴散不同微粒组合剂对急性酒精性胃黏膜损伤模型大鼠血清Ghrelin及胃黏膜病理组织学的影响  

Effects of Different Combination of Compound Lizards Powder on Serum Ghrelin and Pathologic Changes of Gastric Mucosa on Ethanol Induced Acute Gastric Mucosa Injury Model in Rat

作　　者：郭利民[1] 朱西杰[1] 李卫强[1] 朱微微[1] 张静霜[1] 徐丽华[1] 苏维霞[1] 

机构地区：[1]宁夏医科大学中医学院,宁夏银川750004

出　　处：《辽宁中医药大学学报》2011年第7期73-75,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30860360)

摘　　要：目的:研究复方蜥蜴散不同微粒组合剂对大鼠急性胃黏膜损伤的保护作用。方法:SD雄性大鼠随机分为正常组,模型组,预防组(蜥蜴散组一、铝碳酸镁组一、蜥蜴散组二、铝碳酸镁组二)。正常组、模型组灌胃给予生理盐水,蜥蜴散组一、铝碳酸镁组一灌胃给予复方蜥蜴散不同微粒组合剂、铝碳酸镁,30min后正常组灌胃给予生理盐水,其余各组给予无水乙醇灌胃;蜥蜴散组二、铝碳酸镁组二灌胃给予复方蜥蜴散不同微粒组合剂、铝碳酸镁,60min后再给予无水乙醇灌胃。用ELISA检测血清ghrelin的水平并观察胃黏膜组织病理学改变。结果:预防治疗组大鼠血清ghrelin水平明显高于模型组(P<0.01)。复方蜥蜴散不同微粒组合剂能减轻乙醇所致胃黏膜损伤,改善胃黏膜病理组织学损害。结论:复方蜥蜴散不同微粒组合剂对无水乙醇诱导的急性胃黏膜损伤有预防保护作用。Objective ： To explore the protective effect of Different combination of Compound Lizards Powder （ DCLP ） on rat with acute gastric mucosal injure. Methods ： Male SD rat were randomly divided into normal group, model group, treating group （ DCLP group one, Hydrotalcite group one, DCLP group two, Hydrotalcite group two ） .Normal saline was administrated to normal and ethanol to model group via gastric irrigation. DCLP 1 and hydrotolcite 1 were treated with DCLP or hydrotalcite respectively 30 min before ethanol was administrated. DCLP 2 and hydrotolcite 2 were treated with DCLP or hydrotalcite respectively 60 rain before ethanol was administrated. Serum ghrelin was detected via ELISA and histopathological change of gastric mucosa was observed. Result ： Compared with model group, the level of serum ghrelin in the rats of the all treating group was significantly higher （P〈0.01）, and the pathologic changes of injured gastric mucosa were significantly improved. Conclusion ： Different combination of Compound Lizards Powder can protect the ethanol-induced acute gastric mucosa injury.

关 键 词：急性胃黏膜损伤 复方蜥蜴散不同微粒组合剂 血清ghrelin 病理组织学 

分 类 号：R573[医药卫生—消化系统]