VEGF在糖尿病伴发牙周炎患者牙龈组织中的表达  

The Study on the Expression and Meaning of Different Exposures of Human Gingival Tissues to Diabetes Mellitus

作　　者：高秀秋[1] 赵靓[1] 杜暘[1] 

机构地区：[1]辽宁医学院附属第二医院口腔内科,辽宁锦州121000

出　　处：《辽宁医学院学报》2011年第3期196-198,I0001,共4页Journal of Liaoning Medical University (LNMU) Bimonthly

基　　金：辽宁省教育厅课题资助项目;编号:2008418

摘　　要：目的探讨在非胰岛素依赖型(Ⅱ型)糖尿病伴发牙周炎患者牙龈组织中血管内皮生长因子的分布及其在Ⅱ型糖尿病伴发牙周炎患者牙周组织破坏中的作用。方法用免疫组化方法检测糖尿病伴发牙周炎患者牙龈组织VEGF的分布。结果 VEGF在Ⅱ型糖尿病伴牙周炎组牙龈中的阳性表达显著高于牙周炎组。结论糖尿病可能引发牙龈VEGF的表达增强,干预血管形成或血管通透性,从而引发牙龈病变。Objective To detect the distribution and effect of the vascular endothelial growth factor （VEGF） in gingival tissues of patients with NIDDM accompanying periodontitis. Methods Immunohistochemical staining was performed to detect VEGF expression in gingival tissues. Results The number of VEGF positive cells was significantly correlated with the number of apoptosis cells. Conclusions Diabetes mellitus may influence the health of gingival epithelium through the secretion of VEGF.

关 键 词：牙周炎 糖尿病 血管内皮生长因子 

分 类 号：R781.4[医药卫生—口腔医学]