Schiff碱单核与双核配合物的抗菌及催化活性研究  

Studies on the antibacterial and catalytic activity of Schiff base mono-and di-nuclear complexes

作　　者：费宝丽[1,2] 燕庆玲[1] 李雯[1] 王大捷[1] 邵奎占[3] 苏忠民[3] 孙为银[2] 

机构地区：[1]南京林业大学化学工程学院,江苏南京210037 [2]南京大学配位化学国家重点实验室,江苏南京210093 [3]东北师范大学化学学院,吉林长春130024

出　　处：《东北师大学报（自然科学版）》2011年第2期91-95,共5页Journal of Northeast Normal University(Natural Science Edition)

基　　金：国家杰出青年科学基金资助项目(20425101);南京林业大学引进高层次留学回国人员科研基金资助项目;南京大学配位化学重点实验室开放基金资助项目

摘　　要：合成了双核[Cu(HL)(CH3OH)](1)和单核[Cu(HL)2](2)(H2L=水杨醛缩乙醇胺)2个Schiff碱铜配合物.采用元素分析和X射线单晶衍射对配合物的组成和结构进行了表征.采用琼脂扩散法测定了配体和配合物的抑菌活性,同时研究了不同条件下配合物对H2O2分解的催化性能.实验表明:目标化合物对革兰氏阳性菌具有较好的抑制作用,并且配合物1的抑菌活性优于配体和配合物2;在碱性条件下,0.008 g配合物1作为催化剂,对15 mL 15%过氧化氢溶液的催化分解效果最佳,同时配合物1的催化活性明显高于配合物2和相应金属盐的催化活性.Two copper（Ⅱ） complexes [Cu2（L）2（CH3OH）]（dinuclear）（1） and [Cu（HL）2]（mononuclear）（2）（H2L=salicylidene-2-ethanolamine） were synthesized and structurally characterized by elemental analysis and single-crystal X-ray diffraction.The Schiff base ligand and its complexes were tested in vitro to evaluate their antibacterial activities.The primary biological activity experiments showed that all products exhibited better activities against Gram-positive bacteria and the complex 1 was more active than free ligand and complex 2 against the same bacteria.Catalytic activities of the complexes for decomposition of H2O2 solution were investigated at various conditions.The effects of concentration of hydrogen peroxide,catalyst dosage,and basicity-acidity of the solution on the reaction were also investigated.The results indicated that,in basic solution,0.008 g of complex 1 had the best catalytic ability for the decomposition of 15 mL 15% hydrogen peroxide,and the catalytic activity of complex 1 was significantly higher than that of complex 2 and the corresponding metal salts.The antibacterial activity and catalytic results proved that,compared with complex 2,complex 1 is a better candidate to be antibacterial agent and catalyst for the reason of synergistic effect between metal ions.

关 键 词：SCHIFF碱配合物 抑菌活性 催化活性 

分 类 号：O621.3[理学—有机化学]