微生态制剂对婴幼儿肺炎继发腹泻的保护作用及其影响因素  

Risk Factors and Protective Effect of Probiotics Against Diarrhea among Children with Pneumonia

作　　者：刘明[1] 程均[1] 罗勤[1] 

机构地区：[1]江西省萍乡市人民医院,萍乡337000

出　　处：《实用中西医结合临床》2011年第3期10-12,共3页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的：探讨婴幼儿肺炎继发腹泻的危险因素及采用微生态制剂（妈咪爱）对其预防的临床效果。方法：采用病例对照研究方法,收集2007年1月~2009年12月间我院收治的符合婴幼儿肺炎继发腹泻诊断标准的165例患儿作为病例组,选择同期住院的155例未继发腹泻的肺炎患儿作为对照组。用统一问卷摘抄病例组和对照组患儿病案,收集其人口学信息及相关因素。采用非条件Logistic回归对婴幼儿肺炎继发腹泻影响因素进行单因素、多因素分析。结果：单因素分析显示,年龄、病情程度、住院时间、住院时侵入性操作、中性粒细胞、血红蛋白和使用微生态制剂与婴幼儿肺炎继发腹泻有关。多因素非条件Logistic回归分析显示,年龄〈2岁、住院时有侵入性操作和住院时间≥7d是婴幼儿肺炎继发腹泻的危险因素,使用微生态制剂则是保护因素。结论：年龄〈2岁、住院时有侵入性操作和住院时间≥7d是婴幼儿肺炎继发腹泻的危险因素;使用微生态制剂（妈咪爱散剂）可预防婴幼儿肺炎继发腹泻,可作为预防婴幼儿肺炎继发腹泻有效手段之一。Objective：To understand protective effect and risk factors of probiotics against diarrhea among children with pneumonia.Methods：We selected 165 diarrhea cases and 155 controls among inpatients who were admitted during January 2007 to December 2009 and aged two months to three years old.A structured questionnaire was used to collect demographic and other related risk factors.We used conditional logistic regression models to estimate odds ratios and their corresponding 95% confidence intervals for the univariable and multivariable analysis.Results：Univariable analysis indicated that age,level of severity of patient＇s condition,days of hospitalization,invasion operate,percent of neutrophilic granulocyte,and concentration of Hb increased risk of diarrhea of children with pneumonia,but using of probiotics reduced risk of diarrhea.Variables independently associated with diarrhea of children included：age,invasion operate,days of hospitalization,and using of probiotics.Conclusion：Longer duration of hospitalization,younger age,and invasion operations can increase risk of diarrhea of children with pneumonia.Probiotics can be used to reduce incidence of diarrhea of children with pneumonia.

关 键 词：肺炎 腹泻 危险因素 儿童 微生态制剂 

分 类 号：R574.62[医药卫生—消化系统]