CDK2在鼻咽癌中的表达及意义  

The Expression and Significance of CDK-2 in Nasopharyngeal Carcinoma

作　　者：官树雄[1] 蒋月荷[2] 王继群[3] 山艳春[3] 

机构地区：[1]广东医学院附属厚街医院耳鼻咽喉科,广东省东莞市523945 [2]广东医学院附属厚街医院病理科,广东省东莞市523945 [3]暨南大学医学院耳鼻咽喉科,广东省广州市510630

出　　处：《中华全科医学》2011年第7期1010-1011,共2页Chinese Journal of General Practice

基　　金：广东省自然科学基金资助课题(9451063201003299);澳门科研基金委员会资助课题(029/2009/A)

摘　　要：目的探讨细胞周期蛋白依赖性激酶2(CDK2)在鼻咽癌和慢性鼻咽炎黏膜组织中的表达水平,及其与鼻咽癌的临床病理关系。方法免疫组化SP法检测CDK2蛋白在鼻咽癌和慢性鼻咽炎黏膜组织中的表达情况。结果 CDK2蛋白阳性表达主要定位于细胞核,少数有胞浆着色,呈棕黄色或棕褐色不同强度的染色。62例鼻咽癌组织中阳性表达率为69.4%(43/62),慢性鼻咽炎黏膜组织中阳性率为32.0%(9/28),两组间差异有统计学意义(P<0.05)。CDK2蛋白表达与鼻咽癌分化程度,淋巴结转移范围,TNM分期有关(P<0.05)。结论 CDK2在鼻咽癌组织中的表达明显高于慢性鼻咽炎黏膜组织中的表达,提示CDK2与鼻咽癌的发生、发展有关。CDK2与鼻咽癌分化程度,淋巴结转移范围,TNM分期有关。Objective The propose of the research was focused on the expression levels of CDK2 in the tissues of nasopharyngeal carcinoma and chronic inflammation nasopharyngeal membrane.And it may relate to the pathogenesis and clinical significance of nasopharyngeal carcinoma which had been observed in the field of cell cycle.Methods Immunohistochemistry（sp） was used to examine the expression levels of CDK2 protein in the tissues of nasopharyngeal carcinoma and chronic inflammation nasopharyngeal membrane.Results Most of the CDK2 protein positive expression was found in cell nucleus,but some was found in the kytoplasm and its color was brown yellow or dark brown.The positive expression rate of nasopharyngeal carcinoma from 62 patients was 69.40%（43/62）,and that of the chronic inflammation nasopharyngeal membrane was 32.0%（9/28）.The difference of the two groups was found statistical significance（P0.05）;the expression levels of CDK2 were related to the differential degree,the range of lymph node metastases and clinical staging of nasopharyngeal carcinoma,the difference was been found statistical significance（P0.05）.Conclusion The expression levels of CDK2 in the tissues of nasopharyngeal carcinoma was obviously higher than that of the chronic inflammation nasopharyngeal membrane,which means CDK2 may relate to the genesis and development of nasopharyngeal carcinoma.The expression level of CDK2 was related to the differential degree,the range of lymph node metastases and clinical staging of nasopharyngeal carcinoma.

关 键 词：鼻咽癌 CDK2 免疫组织化学 

分 类 号：R739.6[医药卫生—肿瘤] R730.3[医药卫生—临床医学]