Regio-selective chlorination of vinca alkaloids catalyzed by Lewis acid  

作　　者：FANG LiSong ZHANG Qiao DENG ChunLin LEI XinSheng LIN GuoQiang 

机构地区：[1]School of Pharmacy, Fudan Universitv, Shanghai 201203, China [2]Institutes of Biomedical Sciences, Fudan University Shanghai 200032, China

出　　处：《Science China Chemistry》2011年第7期1039-1043,共5页中国科学（化学英文版）

基　　金：the National Natural Science Foundation of China (20872019);Fudan University for the research financial support

摘　　要：Novel C-17-chloro-substituted derivative of vinorelbine or vinflunine has been regio-selectively synthesized via the chlorination reaction in the presence of Lewis acid.The catalyst Cp2TiCl2 plays a key role in the chlorination reaction.Novel C-17-chloro-substituted derivative of vinorelbine or vinflunine has been regio-selectively synthesized via the chlorination reaction in the presence of Lewis acid. The catalyst Cp2TiCl2 plays a key role in the chlorination reaction.

关 键 词：ALKALOIDS HALOGENATION REGIO-SELECTIVITY SUBSTITUTION Lewis acids 

分 类 号：O629.3[理学—有机化学] TS245.9[理学—化学]