经典Wnt信号通路在牙齿发育中的研究新进展  

Recent advances About Canonical Wnt Pathway in Tooth Development

作　　者：王也[1] 李汉梁[1] 林丽娣[1] 林鑫[1] 王冰梅[1] 

机构地区：[1]福建省福建师范大学旗山校区,福建福州350108

出　　处：《现代生物医学进展》2011年第13期2575-2577,共3页Progress in Modern Biomedicine

基　　金：国家级实验教学示范中心项目(2009ls025)

摘　　要：经典Wnt信号通路是参与胚胎及器官发育的四大信号传导途径之一,在牙齿发育中扮演了重要的角色。本文对其中的β-catenin,Lef1,Apc,Axin2这4个关键因子在牙齿发育中研究的新进展做了简要的概述:β-catenin在间充质中会调控多个信号,影响牙上皮和间充质相互作用;Lef1会和Tcf家族一道调控上皮细胞命运;Apc能抑制多余牙齿的形成;Axin2在牙晚期发育中影响牙本质的形成。通过这些因子的研究,希望人们能在牙齿再生等生物医学工程上有新的突破。Canonical Wnt signaling pathway is one of the main four categories of signal transduction pathway involving in embryo and organ development. It also plays an important role in the tooth development. In this paper, we briefly write an overview about the new research of β-catenin,Lefl,Apc,Axin2 in tooth development： β-catenin affects the interaction between epithelium and mesenchyme by regulating other signals; the LEF/TCF complex can regulate the fate of dental epithelium cell; Apc inhibits supernumerary tooth formation during embryo genesis; and Axin2 has the influence of development of the crown and root during pre- and postnatal tooth development.So here we hope it may bring a new breakthrough among tooth regeneration and other bioengineerings.

关 键 词：WNT 牙齿发育 Β-CATENIN 

分 类 号：R78[医药卫生—口腔医学]