p16和Rb基因蛋白在肺癌中的表达  

Significance of p16 and Rb gene protein expression in primary lung cancers

作　　者：苏长青[1,2] 李淑锋[1,2] 叶玉坤[1,2] 单祥年[1,2] 

机构地区：[1]南京八一医院全军肿瘤研究中心 [2]南京师范大学生物系

出　　处：《临床与实验病理学杂志》1999年第3期199-201,I030,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家"九五"重点科技项目;国家自然科学基金

摘　　要：目的：研究ｐ１６和Ｒｂ基因蛋白的表达与肺癌临床病理学特征的关系。方法：采用免疫组织化学方法对８９例肺癌进行了ｐ１６和Ｒｂ蛋白的定位观察。结果：肺癌ｐ１６基因蛋白的总丢失率为４７２％（４２／８９），且与肺癌的组织学类型、淋巴结转移、临床病理分期有关。Ｒｂ基因蛋白的总丢失率为３１５％（２８／８９），与组织学类型有关。ｐ１６和Ｒｂ基因蛋白的表达存在着明显的互补性。结论：ｐ１６和Ｒｂ基因蛋白的丢失是肺癌发生发展中重要的分子事件，与细胞周期Ｇ１→Ｓ期的负反馈调节环路中断关系密切。Purpose To study the expression of p16 and Rb gene proteins in primary lung cancers. Method Eightynine cases of lung cancer were observed by immunohistochemistry. Results The loss of p16 protein in lung cancers was related to histological type, lymph node metastasis and progressive stage, while the loss of Rb protein only to histological type. The inverse correlation of p16 and Rb gene expression in lung cancers was confirmed. Conclusion The loss of p16 or Rb gene protein is an important molecular event in lung cancers, and closely related to the block in the negative regulatory pathway of cell cycle.

关 键 词：肺肿瘤 P16蛋白 RB蛋白 免疫组织化学 

分 类 号：R734.202[医药卫生—肿瘤]