Effect of Tumor Necrosis Factor-α Antagonism in Asthma:a Meta-analysis of the Published Literature  

作　　者：陈晓菊 熊亮 覃寿明 马万里 周琼 

机构地区：[1]Department of Respiratory Diseases,Union Hospital,Key Lab of Pulmonary Diseases of Health Ministry,Tongji Medical College,Huazhong University of Science and Technology [2]The Affiliated Tumor Hospital of Guangxi Medical University [3]First Affiliated Hospital,Guangxi Medical University

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第1期137-141,共5页华中科技大学学报（医学英德文版）

基　　金：supported by a grant from National Science Fund for Distinguished Young Scholars (No. 30925032);by grants from National Natural Sciences Foundation of China (No. 30872343 and No. 30770648)

摘　　要：It remains controversial whether tumor necrosis factor（TNF）-α antagonism is effective for asthma.This meta-analysis was performed to evaluate efficacy of TNF-α antagonism in treatment of patients with asthma.MEDLINE,EMBASE,LILACS,and CINAHL databases were searched for English-language studies published through January 3,2010.Randomized-controlled trials comparing TNF-α antagonism with control therapy were selected.For each report,data were extracted in relation to the outcomes analyzed：asthma exacerbation,asthma quality of life questionnaire scores,and forced expiratory volume in 1 second.Four assessable trials were identified including 641 patients with asthma.TNF-α antagonism therapy was superior to control therapy in preventing exacerbations in asthmatics [pooled odds ratio 0.52（95% confidence interval 0.29-0.88）,P=0.02]however,there was a nonsignificant reduction in asthma quality of life questionnaire scores [0.23（0 to 0.47）,P=0.05],forced expiratory volume in 1 second [0.03,（-0.14 to 0.10）,P=0.74] when analyzed using standardized mean differences.TNF-α antagonism was superior to control chemotherapy in terms of asthma exacerbation,but not asthma quality of life questionnaire scores or forced expiratory volume in 1 second.It remains controversial whether tumor necrosis factor（TNF）-α antagonism is effective for asthma.This meta-analysis was performed to evaluate efficacy of TNF-α antagonism in treatment of patients with asthma.MEDLINE,EMBASE,LILACS,and CINAHL databases were searched for English-language studies published through January 3,2010.Randomized-controlled trials comparing TNF-α antagonism with control therapy were selected.For each report,data were extracted in relation to the outcomes analyzed：asthma exacerbation,asthma quality of life questionnaire scores,and forced expiratory volume in 1 second.Four assessable trials were identified including 641 patients with asthma.TNF-α antagonism therapy was superior to control therapy in preventing exacerbations in asthmatics [pooled odds ratio 0.52（95% confidence interval 0.29-0.88）,P=0.02]however,there was a nonsignificant reduction in asthma quality of life questionnaire scores [0.23（0 to 0.47）,P=0.05],forced expiratory volume in 1 second [0.03,（-0.14 to 0.10）,P=0.74] when analyzed using standardized mean differences.TNF-α antagonism was superior to control chemotherapy in terms of asthma exacerbation,but not asthma quality of life questionnaire scores or forced expiratory volume in 1 second.

关 键 词：ASTHMA IMMUNOTHERAPY META-ANALYSIS tumor necrosis factor-α 

分 类 号：R562.25[医药卫生—呼吸系统]