自体角膜缘干细胞移植与羊膜移植治疗翼状胬肉的对比研究  

Comparative Study on treatment of pterygium with auto-corneallimbus stem cell transplantation and amnion transplantation

作　　者：蔡春梅[1] 付湘媛[2] 张晶[2] 邓江稳[2] 

机构地区：[1]解放军第二炮兵总医院,100088 [2]中国人民解放军第五三五医院

出　　处：《眼科》2011年第3期196-198,共3页Ophthalmology in China

摘　　要：目的比较自体角膜缘干细胞移植、羊膜移植和单纯翼状胬肉切除三种手术方式治疗翼状胬肉的治愈及复发情况。设计回顾性病例系列。研究对象自2007年8月至2010年8月在解放军第二炮兵总医院眼科应用上述三种手术方法治疗并有随访记录的翼状胬肉患者193例(217眼)。方法根据手术方法的不同,将193例(217眼)翼状胬肉患者分为3组:角膜缘干细胞移植组(A组)73例81眼;羊膜移植组(B组)54例63眼;单纯翼状胬肉切除组(C组)66例73眼。术后平均随访1年(12.2±2.3)月,观察并比较三组患者的治疗效果、复发率和并发症情况。主要指标复发率和并发症。结果随访期间,A组复发4眼,复发率为4.94%;B组复发10眼,复发率为15.9%;C组复发23眼,复发率为31.5%(A与B组、A与C组、B与C组相比,χ2值分别为4.828、18.746、4.498,P值分别为0.028、0.000、0.034)。随访期内,A组未发生睑球粘连,B组有1眼(1.59%)出现睑球粘连,C组有8眼(10.96%)出现睑球粘连。结论与单纯翼状胬肉切除术和羊膜移植术相比,自体角膜缘干细胞移植治疗翼状胬肉并发症少、复发率低,是治疗翼状胬肉较好的手法方法。Objective To compare the curative and recurrent situation for the treatment of pterygium among three operative methods （simple excision of pterygium,combined excision of pterygium with auto-corneallimbus stem cell transplantation, and combined excision of pterygium with amnion transplantation）. Design Retrospective case series. Participants 193 cases （217 eyes ） with pterygium, who underwent the operation in The Second Artillery General Hospital of PLA from Aug. 2007 to Aug. 2010. Methods 193 cases （217 eyes ） with pterygium were divided into 3 groups according to the operative method： combined excision of pterygium with au-to-comedlimbus stem cell transplantation （group A ）73 cases （81 eyes）, combined excision of pterygium with amnion transplantation （group B） 54 cases （63 eyes）, simple excision of pterygium （group C） 66 cases （73 eyes）. After following up for one year, curative effects, recurrent rate and complications were compared among 3 groups. Main Outcome Measures Curative effect, recurrent rate and compli-cations. Results Following up for 1 year after operation, four cases （4 eyes） recurred in group A, recurrence rate 4.94%; 10 case （10 eye ） in group B, recurrence rate 15.9%; 20 cases （23 eye） in group C, recurrence rate 31.5% （P〈 0. 01）. No symblepharon case in group A, one case of symblepharon in group B, and 10 cases of symblepharon in group C. Conclusion Excision of pterygium combined with au-to-corneallimbus stem cell transplantation is an effective method to treat pterygium, which can reduce the complications and the recur-rence. （Ophthalmol CHN, 2011, 20： 196-198）

关 键 词：翼状胬肉 角膜缘干细胞 羊膜移植 

分 类 号：R779.6[医药卫生—眼科]