铁超载与肝细胞癌关系的研究进展  

Recent progress in relationship between iron overload and hepatocellular carcinoma

作　　者：赵睿[1] 张岭漪[1] 

机构地区：[1]兰州大学第二医院肝病科甘肃省消化系肿瘤重点实验室,兰州730030

出　　处：《临床肝胆病杂志》2011年第6期670-673,共4页Journal of Clinical Hepatology

基　　金：甘肃省自然科学基金(1010RJZA087)

摘　　要：肝细胞癌(HCC)的发生与多种因素有关。早期的流行病学研究显示非洲人群饮食中铁过量与HCC发生相关,继而研究发现许多与铁沉积相关的疾病如遗传性血色素沉积症(HH)、丙型病毒性肝炎、非酒精性脂肪性肝病(NAFLD)等在发展过程中均有发生HCC的可能性,提示铁超载可能在其中发挥着直接或间接的作用。现认为铁超载的发生与基因突变、铁代谢相关基因蛋白的异常表达、氧化应激反应、免疫紊乱、促进癌细胞生长等因素有关。本文就铁超载与HCC的相关研究现状作一综述。Hepatocellular carcinoma（HCC） is associated with many specific etiologies.Some epidemiological investigations has shown that dietary iron overload is associated with HCC in Africans.And subsequent studies found that many iron-loading diseases,such as hereditary hemochromatosis,chronic hepatitis C,nonalcoholic fatty liver disease etc,appeared to increase the risk of HCC with the development of these diseases.The carcinogenic potential of these iron-loading diseases is probably mainly associated with genetic mutation,abnormal expression of iron metabolism related proteins,oxidative stress reaction,immune disorder and so on.We summarized the recent findings concerning the correlation between iron-loading diseases and HCC

关 键 词：肝肿瘤 铁 

分 类 号：R735.7[医药卫生—肿瘤]