液基细胞学检查系统在肺癌诊断中的价值  

Diagnostic value of liquid-based cytologic test in lung cancer

作　　者：董正伟[1] 王彦丽[1] 武春燕[1] 陈岗[1] 

机构地区：[1]同济大学附属上海市肺科医院病理科,上海200433

出　　处：《癌变．畸变．突变》2011年第3期232-234,共3页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：上海市市级医院适宜技术联合开发推广应用项目(SHDC12007220);上海市科委医学引导类(10411967700)

摘　　要：目的:探讨液基细胞学检查系统在肺癌患者痰液细胞学检查中的应用价值。方法:收集我院2009年送检的痰常规涂片以及痰液基细胞学涂片,由同一医师组筛选出其中的肺癌阳性涂片,并进行分型归纳。结果:13244例痰常规细胞学涂片中诊断肺癌阳性标本454例,阳性率为3.428%,其中鳞癌170例,占常规涂片总量的1.284%,腺癌130例,占常规涂片总量的0.982%。3227例痰液基细胞学涂片中诊断肺癌阳性标本210例,阳性率为6.508%,明显高于常规细胞学涂片检查(P<0.01),其阳性标本中鳞癌63例,占痰液基细胞学涂片总量的2.824%,腺癌89例,占痰液基细胞学涂片总量的3.989%;肿瘤科和其他非肿瘤科室送检的痰液基细胞学涂片的肺癌阳性率分别为11.022%和4.121%。结论:痰液基细胞学有助于提高痰液细胞病理学诊断的阳性率,而且可用于肺癌高危人群的筛查和早期诊断。OBJECTIVE：We discussed the value of liquid cytology system in the sputum of patients with lung cancer.METHODS：Samples which were treated with conventional preparation and those that were treated with LCT in 2009 were collected.All of the sputum specimens were diagnosed by the same cytologic pathologists.RESULTS：A total of 13 244 sputum specimens were evaluated with conventional preparation,454（3.428%）of which were positive.170 were squamous cell carcinoma,the positive rate was 1.284%,130 were adenocarcinoma,the positive rate was 0.982%. Also 210 samples were positive among 3 227 sputums specimens treated with LCT,the positive rate was 6.508%,63 were squamous cell carcinoma,the positive rate was 2.824%,89 were adenocarcinoma,the positive rate was 3.989%. The overall positive rate of the sputum specimeus delivered by oncology department was 11.022%.CONCLUSION：LCT smear contributed to increasing the positive rate of sputum cytology and it will be helpful in the screening and early diagnosis of high-risk populations with lung cancer.

关 键 词：肺癌 细胞病理学 痰 液基细胞学检测系统 

分 类 号：R734.2[医药卫生—肿瘤]