Propofol and arrhythmias： two sides of the coin  

作　　者：Qiang LIU Ai-ling KONG Rong CHEN Cheng QIAN Shao-wen LIU Bao-gui SUN Le-xin WANG Long-sheng SONG Jiang HONG 

机构地区：[1]Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China [2]School of Biomedical Sciences, Charles Sturt University, wagga Wagga, NSW, Australia [3]Division of Cardiology, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, USA

出　　处：《Acta Pharmacologica Sinica》2011年第6期817-823,共7页中国药理学报（英文版）

摘　　要：The hypnotic agent propofol is effective for the induction and maintenance of anesthesia. However, recent studies have shown that propofol administration is related to arrhythmias. Propofol displays both pro- and anti-arrhythmic effects in a concentration-dependent manner. Data indicate that propofol can convert supraventricular tachycardia and ventricular tachycardia and may inhibit the conduction system of the heart. The mechanism of the cardiac effects remains poorly defined and may involve ion channels, the autonomic nervous system and cardiac gap junctions. Specifically, sodium, calcium and potassium currents in cardiac cells are suppressed by clinically relevant concentrations of propofol. Propofol shortens the action potential duration （APD） but lessens the ischemia-induced decrease in the APD. Furthermore, propofol suppresses both sympathetic and parasympathetic tone and preserves gap junctions during ischemia. All of these effects cumulatively contribute to the antiarrhythmic and proarrhythmic properties of propofol.The hypnotic agent propofol is effective for the induction and maintenance of anesthesia. However, recent studies have shown that propofol administration is related to arrhythmias. Propofol displays both pro- and anti-arrhythmic effects in a concentration-dependent manner. Data indicate that propofol can convert supraventricular tachycardia and ventricular tachycardia and may inhibit the conduction system of the heart. The mechanism of the cardiac effects remains poorly defined and may involve ion channels, the autonomic nervous system and cardiac gap junctions. Specifically, sodium, calcium and potassium currents in cardiac cells are suppressed by clinically relevant concentrations of propofol. Propofol shortens the action potential duration （APD） but lessens the ischemia-induced decrease in the APD. Furthermore, propofol suppresses both sympathetic and parasympathetic tone and preserves gap junctions during ischemia. All of these effects cumulatively contribute to the antiarrhythmic and proarrhythmic properties of propofol.

关 键 词：PROPOFOL ARRHYTHMIAS ion channels gap junction autonomic nervous system 

分 类 号：Q959.194[生物学—动物学] TQ463.4[化学工程—制药化工]