基于β-环糊精/SiO_2手性固定相的薄层色谱法拆分DL-萘普生的研究  

Resolution of DL-naproxen using thin layer chromatography with β-cyclodextrin/SiO_2 as chiral stationary phase

作　　者：王丽丽[1] 何毅[2] 谢达栋[2] 王皖[2] 邓健[1] 

机构地区：[1]南华大学化学化工学院,湖南衡阳421001 [2]南华大学船山学院,湖南衡阳421001

出　　处：《应用化工》2011年第6期1011-1014,共4页Applied Chemical Industry

基　　金：湖南省大学生研究性学习与创新性实验计划基金项目(湘教通〔2009〕154号)

摘　　要：用β-环糊精(-βCD)键合硅胶合成了一种新型的β-环糊精/S iO2手性固定相,用红外对其进行了结构鉴定。将该手性固定相用于薄层色谱分离萘普生外消旋体,考察多种溶剂对萘普生外消旋体的展开效果,结果表明,乙酸乙酯∶氯仿(体积比)=1∶4为展开剂时,合成的手性固定相对DL-萘普生的分离度为1.45,具有很好的拆分DL-萘普生的能力。A new kind of β-CD/SiO2 chiral stationary phase was synthesized bonded on the silica gel and characterized by IR spectrometry.It was used as chiral stationary phase of thin-layer chromatography to separate racemic naproxen.The separation of DL-naproxen by several different mobile phase was studied,and the best volume ratio of ethyl acetate to chloroform was 1∶4.The results showed that it had an excellent separate capability and the separate faction of DL-naproxen was up to 1.45.

关 键 词：DL-萘普生 Β-环糊精 薄层色谱 手性拆分 

分 类 号：TQ460.7[化学工程—制药化工]