乙肝病毒携带孕妇检出病毒阳性年龄及疫苗接种调查  

Investigation on detection age of positive HBV and vaccine inoculation of HBV-infected pregnant women

作　　者：陈红[1] 任群[2] 

机构地区：[1]北京市海淀区妇幼保健院,100080 [2]湖北省襄阳市中心医院

出　　处：《中国妇幼保健》2011年第18期2808-2810,共3页Maternal and Child Health Care of China

基　　金：北京市卫生局妇幼科研基金资助项目(C03011403)

摘　　要：目的:了解乙型肝炎病毒母婴和父婴传播中垂直传播和水平传播的比例和乙肝病毒携带孕妇乙肝疫苗接种情况。方法:对父母也为乙肝病毒携带者的乙型肝炎病毒携带孕妇的乙肝病毒检出年龄进行调查,并对乙肝病毒携带孕妇乙肝病毒检出前乙肝疫苗接种情况也进行了调查。结果:①165例被调查乙肝病毒携带孕妇中,否认在检出乙肝病毒阳性前家庭有乙肝病毒接触史72例,占43.64%。有非家庭乙肝病毒接触史11例,占6.67%。家庭中有乙肝病毒携带者76例,占46.06%,其中母亲为乙肝病毒携带者42例,占25.45%,父亲为乙肝病毒携带者21例,占12.73%,丈夫为乙肝病毒携带者13例,占7.88%。做过外科手术6例,占3.64%。②母亲为乙肝病毒携带者加父亲为乙肝病毒携带者63例中,4例1岁以前检出乙肝病毒阳性,占6.35%,1岁以后检出乙肝病毒阳性59例,占93.65%,差异有统计学意义(χ2=96.032,P=0.000)。其中6例7岁以前检出乙肝病毒阳性,占9.52%,其余57例均在7岁以后检出乙肝病毒阳性,占90.48%,经统计学处理,7岁以前与7岁以后检出乙肝病毒阳性差异仍有统计学意义(χ2=76.222,P=0.000)。③165例被调查乙肝病毒携带孕妇中有98例明确自己检出乙肝病毒阳性前是否接种过乙肝疫苗,占被调查乙肝病毒携带孕妇的59.39%。其中检出乙肝病毒阳性前接种过乙肝疫苗者39例,占39.80%,但均未在检出前3年内接种乙肝疫苗。未接种过乙肝疫苗者59例,占60.20%。结论:乙肝病毒母婴传播和父婴传播中水平传播多于垂直传播。全程接种乙肝疫苗后不可能终生免疫,乙肝病毒密切接触者需要定期检测乙肝保护性抗体定量,及时加强免疫。Objective：To understand the ratio of vertical transmission and horizontal transmission in mother-to-fetus transmission and father-to-fetus transmission of hepatitis B virus（HBV） and the vaccine inoculation situation of HBV-infected pregnant women.Methods：The detection age of HBV in HBV-infected pregnant women whose parents were all infected by HBV were investigated,and the vaccine inoculation situation of HBV-infected pregnant women before detection of HBV were surveyed.Results：Among 165 HBV-infected pregnant women investigated,72 pregnant women denied family contact history of HBV before detection of HBV,accounting for 43.64%.11 pregnant women had non-family contact history of HBV,accounting for 6.67%.76 pregnant women had family members infected by HBV,accounting for 46.06%;42 mothers of the pregnant women had contact history of HBV,accounting for 25.45%;21 fathers of the pregnant women had contact history of HBV,accounting for 12.73%;13 husbands of the pregnant women had contact history of HBV,accounting for 7.88%.6 pregnant women had received surgical operation,accounting for 3.64%.Among 63 HBV-infected pregnant women whose parents were all infected by HBV,4 pregnant women were found with positive HBV before one year,accounting for 6.35%;59 pregnant women were found with positive HBV after one year,accounting for 93.65%,there was significant difference（χ2=96.032,P=0.000）.6 pregnant women were found with positive HBV before 7 years,accounting for 9.52%;57 pregnant women were found with positive HBV after 7 years,accounting for 90.48%,there was significant difference（χ2=76.222,P=0.000）.Among 165 HBV-infected pregnant women investigated,98 pregnant women knew whether themselves had been inoculated with HBV vaccine,accounting for 59.39%.39 pregnant women inoculated HBV vaccine before detection of HBV,accounting for 39.80%,but they didn＇t inoculate HBV vaccine within 3 years before detection of HBV.59 pregnant women didn＇t inoculate HBV vaccine,accounting for 60.20%.Conclusion：Horizontal

关 键 词：乙型肝炎病毒 疾病传播 垂直 水平 母亲和父亲 儿童 

分 类 号：R575.1[医药卫生—消化系统]