阿尔茨海默病患者血清C_3、Aβ1-42测定及意义  

Serum levels of complement C_3 and Aβ1-42 in patients with Alzheimer disease.

作　　者：张霞辉[1,2] 李东风[1] 王宝萍[1] 向绍通[1] 徐书雯[1] 

机构地区：[1]广东省人民医院广东省医学科学院东病区神经内科,广州510080 [2]南方医科大学

出　　处：《广东医学》2011年第12期1546-1547,共2页Guangdong Medical Journal

基　　金：广东省医学科学基金资助项目(编号:C2009031);广州市科技计划项目(编号:2010Y1-C101)

摘　　要：目的测定并分析阿尔茨海默病(Alzheimer's disease,AD)血清中C3和Aβ1-42的变化规律。方法收集AD患者与正常老年人的血清,并利用夹心ELISA技术测定补体C3与Aβ1-42浓度。结果 AD患者血清中补体C3浓度较正常老年人虽有所增加,但差异无统计学意义(P>0.05);AD患者血清中Aβ1-42浓度较正常老年人增加,差异有统计学意义(P<0.05)。结论血清Aβ1-42浓度可以作为AD诊断的参考指标之一。Objective To evaluate serum complement C3 and AI31 -42 in patients with Alzheimer disease （AD）. Methods Serum samples of patients with Alzheimer disease and normal elders were collected for assessment of complement C3 and AβI -42 using ELISA. Results Although higher level of complement C3 was revealed in AD group. than that in controls, no significant difference was detected （P 〉0.05）. However, significantly increase of Aβ1 -42 was revealed in AD group when comparing with that normal controls （P 〈 0. 05 ）. Conclusion Serum Aβ1 -42 is a provides biochemical marker for the diagnosis of AD.

关 键 词：阿尔茨海默病 补体C3 AΒ1-42 

分 类 号：R749.16[医药卫生—神经病学与精神病学]