卵磷脂对妊娠期高血压疾病高风险孕妇血浆前列环素、血栓素水平的影响  

Impacts of lecithin on the concentration of 6-keto-PGF_(1α) and TXB_2 in pregnancy MP predicting positive HDIP

作　　者：李巍巍[1] 任丽娜[1] 

机构地区：[1]中国医科大学附属第一医院产科,辽宁沈阳110001

出　　处：《大连医科大学学报》2011年第3期232-234,共3页Journal of Dalian Medical University

基　　金：辽宁省教育厅基金(L2010612)

摘　　要：[目的]探讨妊娠期高血压疾病高风险孕妇摄取卵磷脂对其血浆前列环素(PGI2)代谢产物(6-keto-PGF1α),血栓素(TXA2)代谢产物(TXB2)水平的影响及改善妊娠结局的可能性。[方法]选取既往无高血压、无心、肝、肾疾病单胎孕妇于妊娠20~22周应用SD-Ⅱ型妊娠期高血压预测分析系统进行预测,检测出妊娠期高血压疾病高风险(阳性)204例,从中随机选取102例作为实验组,余102例作为对照组,实验组每日口服卵磷脂2 g,两组均进行饮食调节,运动干预,两组分别于实验前(妊娠20~22周)、实验后(妊娠36~40周)测定血浆前列环素、血栓素水平,统计并比较两组妊娠期高血压、子痫前期、子痫、胎盘早剥发生率等妊娠结局。[结果]妊娠36~40周,实验组TXB2浓度明显降低,6-Keto-PGF1α浓度明显升高,与对照组相比差异有显著性意义(P<0.05);实验组TXB2/6-keto-PGF1α明显低于对照组,差异有显著性意义(P<0.05)。实验组妊娠期高血压、子痫前期、子痫、胎盘早剥发生率低于对照组,差异有显著性意义(P<0.05)。[结论]妊娠期高血压疾病高风险孕妇者摄入卵磷脂,对降低妊娠期高血压疾病发病率,改善母儿结局有一定作用。[Objective] To study the effect of soybean lecithin on the concentration of 6-keto-PGF1α and TXB2 in pregnancy SD-Ⅱ predicting positive HDIP and then improve the outcome of both mother and fetus.[Methods] Two hundred and four pregnant women who had only one fetus,and without hypertension and disease in heart,liver and kidney,were analyzed with SD-Ⅱpredicting HDIP positive at the 20th^22nd week of their pregnancy.They were divided into 2 groups equally.The experimental group took 2 g soybean lecithin every day until the 36th^40th week,Their 6-keto-PGF1α,TXB2,levels were measured.We calculated and compared the incidents of gestational hypertension,preeclampsia,eclampsia and placental abruption in two groups.[Results] At the 36th^40th week,The concentration of TXB2 in experimental group was significantly lower than that of control group（P0.05）.The concentration of 6-keto-PGF1α in experimental group was significantly higher than that of control group（P0.05）.The rate of TXB2/6-keto-PGF1α in experimental group was significantly lower than that of control group（P0.05）.[Conclution] Uptaking soybean lecithin may reduce the incident of HDIP and improve the outcome of both mother and fetus obviously.

关 键 词：妊娠期高血压疾病高风险 卵磷脂 前列环素 血栓素 

分 类 号：R714.246[医药卫生—妇产科学]