口腔扁平苔藓患者血清RANTES及IL-16表达水平及其临床意义  

Expression and significance of serum RANTES and IL-16 in patients with oral lichen planus

作　　者：张成仁[1] 葛娅娜[1] 靳慧[1] 王秀梅[1] 张梅兮[1] 

机构地区：[1]哈尔滨医科大学附属第二医院口腔科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2011年第2期142-145,共4页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金资助项目(D2007-01);黑龙江省博士后资助基金(LRB05-279);黑龙江省博士后科研启动基金(LRB05-279)

摘　　要：目的检测口腔扁平苔藓(oral lichen planus,OLP)患者血清调节活化正常T细胞表达和分泌因子(regulated on activation,normal T-cell expressed and secreted,RANTES)及白细胞介素-16(interleukin16,IL-16)的表达水平变化,探讨其在OLP病理过程中的作用及其临床意义。方法口腔扁平苔藓患者62例,按照病情严重程度分为5组,另选22例健康志愿者作对照组,采用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测各组的血清RANTES及IL-16水平。结果 OLP患者血清RAN-TES和IL-16水平均较健康对照组显著增高(P<0.05),并且RANTES与IL-16水平与临床病损严重程度呈正相关(r=0.2647,P<0.0151;r=0.2580,P<0.0241)。结论 RANTES和IL-16参与OLP的炎症反应及其病理过程,可能为OLP病损严重程度的评价提供参考。Objective To explore the levels of regulated on activation,normal T-cell expressed and secreted（RANTES）and interleukin-16（IL-16）in serum from patients with oral lichen planus（OLP） and to identify their pathological role and the clinical significance.Methods Sixty two patients with oral lichen planus were divided into 5 groups according to OLP severity and 22 healthy volunteers were used as control.Serum levels of RANTES and IL-16 were measured by enzyme linked immunosorbent assay（ELISA）.Results Serum levels of RANTES and IL-16 were significantly increased in OLP patients compared with healthy subjects（P0.05）.And positive statistical correlations existed between the level of RANTES,IL-16 and clinical severity（r=0.2647,P0.0151;r=0.2580,P0.0241）.Conclusion RANTES and IL-16 are involved in the inflammatory reaction and the pathogenesis of OLP,and the levels of RANTES and IL-16 may be useful biomarkers for OLP severity.

关 键 词：扁平苔藓 口腔 调节活化正常T细胞表达和分泌因子 白介素-16 趋化因子 

分 类 号：R781.5[医药卫生—口腔医学]