内皮特异性分子-1在乳腺浸润性导管癌中的表达与淋巴管增生的关系  

Expression of Endothelial-specific Molecule-1 in Human Invasive Lobular Breast Cancer and Relationship with Lymphangiogenesis

作　　者：陈超阳[1] 陈维荣[1] 廖梓群[1] 吴建军[1] 陈喜贵[1] 李彦冲[1] 

机构地区：[1]汕头大学医学院第二附属医院普外科,广东汕头515041

出　　处：《汕头大学医学院学报》2011年第2期100-102,107,F0003,共5页Journal of Shantou University Medical College

摘　　要：目地:探讨内皮特异性分子(ESM)-1在乳腺浸润性癌淋巴管生成和淋巴道转移中的作用及其与临床病理指标的关系。方法:免疫组化检测108例乳腺浸润性导管癌者的ESM-1表达,D2-40标记淋巴管内皮,并计数微淋巴管密度(LMVD),分析上述指标与临床病理特征的关系。结果:ESM-1主要表达于肿瘤细胞中。ESM-1表达与肿瘤大小,淋巴结转移,LMVD相关(P<0.001)。结论:ESM-1能促进乳腺癌淋巴管增生,并与肿瘤大小和淋巴道转移相关。Objective：To evaluate the role of endothelial-specific molecule-1（ESM-1）in lymphangiogenesis of infiltrating ductal carcinoma,and to investigate its relationship with clinical value.Methods：Immunohistochemistry was performed in paraffin-embedded tissue specimens from 108 patients with infiltrating ductal carcinoma to detect the proteins ESM-1.D2-40 was used to mark lymphatic endothelial cell and the lymphatic vessel density（LVMD）was counted.The results were statistically processed.Results： A positive immunoreaction of ESM-1 was observed,predominantly in malignant cells.ESM-1 was positively correlated to larger tumor size,LMVD and lymph nodes metastasis（P〈0.001）.Conclusion：ESM-1 can promote lymphangiogenesis in breast cancer,and associates with tumor size and lymph node metastasis.

关 键 词：内皮特异性分子-1 乳腺浸润性癌 淋巴管增生 微淋巴管密度 

分 类 号：R737.9[医药卫生—肿瘤]