血小板血管生成调节蛋白在慢性粒细胞白血病中的研究  

Research of Platelet Angiogenetic Protein Expression in Chronic Myeloid Leukemia

作　　者：王雪华[1] 降芳[1] 焦晓阳[1] 

机构地区：[1]汕头大学医学院第一附属医院检验科,广东汕头515041

出　　处：《汕头大学医学院学报》2011年第2期113-115,共3页Journal of Shantou University Medical College

基　　金：广东省自然科学基金资助项目(9151008901000043);广东省科技计划资助项目(2010B031600321)

摘　　要：目的:探讨血小板血管生成调节蛋白在慢性粒细胞白血病(CML)病程中的变化及其预后意义。方法:用ELSIA检测CML患者及正常对照组乏血小板血浆(PPP)和血小板提取液中血管生成调节蛋白血管内皮生长因子(VEGF)的浓度。结果:VEGF浓度在PPP和血小板提取液中均表现为CML组明显高于正常对照组(P<0.05);在CML组内则表现为急变期显著高于慢性期和加速期(P<0.01);VEGF水平在血小板提取液中明显高于PPP。结论:CML各期血小板提取液中VEGF水平较PPP内变化更敏感,且随病情发展而增高,其变化有助于监测CML的病情进展和预后判断。Objective：To explore the expression and prognostic significance of angiogenetic protein produced by platelet in chronic myeloid leukemia（CML）.Methods：The levels of vascular endothelial growth factor（VEGF）in platelet-poor plasma（PPP）and platelet extract were detected between CML patients and controls by ELISA method.Results：VEGF levels in PPP and platelet extract in the CML group were significantly higher than those of controls（P〈0.05）.In each phase of CML,the highest level of VEGF was found in blast phase,higher significantly than these of chronic and accelerated phase（P〈0.01）.VEGF in platelet extract was markedly higher than that in PPP.Conclusion：The changes of VEGF in platelet extract is more sensitive than that in PPP,increased by progression of disease which may conduce to prognosis judgment.

关 键 词：血小板 慢性粒细胞白血病 血管内皮生长因子 

分 类 号：R733.72[医药卫生—肿瘤]