联检血清VEGF、CA15-3、TSGF及放射性核素骨扫描对乳腺癌骨转移诊断的临床价值  

Clinical Values of Combined Detection of Serum VEGF,CA15-3,TSGF Levels and Whole Body Bone Scan in Diagnosis of Bone Metastasis for Breast Cancer

作　　者：竺蓓[1] 王爱华[1] 耿红莲[1] 

机构地区：[1]上海长征医院,200003

出　　处：《放射免疫学杂志》2011年第3期318-319,共2页Journal of Radioimmanology

摘　　要：目的:探讨了联检血清VEGF、CA15-3、TSGF及放射性核素显像对诊断乳腺癌骨转移的临床价值。方法:应用发光免疫分析技术和酶联法检测了82例乳腺癌患者血清VEGF、CA15-3、TSGF这三种肿瘤标志物,应用SPECT对既有患者进行了骨扫描检测,以明确有无转移。结果:82例乳腺癌患者血清VEGF、CA15-3、TSGF水平均显著地高于正常人组(P≤0.01),32例临床诊断为乳腺癌骨转移组又非常显著地高于正常人组(P≤0.01)。结论:检测血清VEGF、CA15-3、TSGF水平结合全身骨扫描可提高对乳腺癌骨转移诊断的准确性,具有重要的临床价值。Objective To explore the clinical values of serum VEGF,CA15-3,TSGF and whole body scan in diagnosis of bone metastasis for breast cancer.Methods Serum CA15-3,TSGF（with CLIA）,serum VEGF（with ELISA） levels were measured simultameously and whole body bone scan was investigated by SPECT in 82 breast cancer patients.Results In 82 patients.32 patients were diagnosed positive for bone metastasis with whole body bone scan.Serum VEGF,CA15-3,TSGF levels in patients with breast cancer were significantly higher than those in controls（P0.001）.Conclusion Determination of serum VEGF,CA15-3 and TSGF is helpful for diagnosis of bone metastasis from breast cancer.Combined detection of VEGF,CA15-3,TSGF and whole body bone scan could increase the sensitivity and accuracy of diagnosing bone metastasis might be of clinical importance values.

关 键 词：乳腺癌 血管内皮生长因子 糖类抗原15-3 肿瘤特异性生长因子 全身骨扫描 骨转移 

分 类 号：R737.9[医药卫生—肿瘤]