侵袭性天然杀伤细胞白血病  

A case of aggressive NK cell leukaemia

作　　者：黄金波 冯祥艳 杨栋林 冯四洲 

机构地区：[1]中国医学科学院、北京协和医学院血液学研究所血液病医院,天津300020

出　　处：《临床皮肤科杂志》2011年第7期426-428,共3页Journal of Clinical Dermatology

摘　　要：报告1例侵袭性天然杀伤细胞白血病。患者男,37岁。全身散在暗红色丘疹5个月,乏力并加重1个月。浅表淋巴结未触及,脾脏肋下6 cm,肝脏肋下未触及。根据患者骨髓组织病理、免疫组化、免疫分型和电镜检查结果诊断为侵袭性天然杀伤(NK)细胞白血病(aggressive natural killer·cell leukaemia),皮肤免疫组化及电镜检查提示侵袭性NK细胞白血病皮肤侵犯。该例资料提示皮损组织病理检查对揭示皮肤淋巴瘤侵犯是不够的,免疫组化及电镜检查在确立诊断中起重要作用。The patient, a 37-year-old male, presented with reddish papule for 5 months, accompanied by progressive fatigue for 1 month. No lymph node involvement was observed. Spleen was larger than that of normality apparently, but liver normal. Basing on the bone marrow biopsy, immunohistochemistry, immunophenotyping and electron microscope, the disease was diagnosed as aggressive natural killer （NK） cell leukaemia. The skin was involved, which was not enough by skin biopsy, it demonstrated by immunohistochemistry and electron microscope examination.

关 键 词：NK细胞白血病 免疫组化 电镜 

分 类 号：R733.7[医药卫生—肿瘤]