Nrf2/ARE转导通路在中枢神经系统疾病中作用的研究进展  

Progress in Research on Role of Nrf2/ARE Transduction Pathway in Central Nervous System Diseases

作　　者：朱凤臣[1] 综述 蒋电明[1] 审校 

机构地区：[1]重庆医科大学附属第一医院骨科,重庆400016

出　　处：《中国生物制品学杂志》2011年第6期741-744,共4页Chinese Journal of Biologicals

摘　　要：转录因子红细胞系-2p45相关因子2(Nuclear factor erythroid-2p45-related factor 2,Nrf2)是细胞调节抗氧化应激反应的重要转录因子,其与抗氧化反应元件(Antioxidant response element,ARE)结合,调控第Ⅱ相解毒酶及抗氧化酶基因的表达,是机体抵抗内外氧化应激的关键保护性通路。中枢神经系统氧耗高,多不饱和脂肪酸含量丰富,对氧化应激极为敏感,Nrf2/ARE转导通路在中枢神经系统中作用的研究越来越受到重视。本文对Nrf2/ARE转导通路的调控机制及其在中枢神经系统疾病中作用的最新研究进展作一综述。Nuclear factor erythroid-2p45-related factor 2（Nrf2）is an important transcription factor for cells to mediate the resistance to oxidative stress.As a pivotal protective pathway to resist internal and external oxidative stress,it binds to antioxidant response element（ARE） and regulates the expressions of phase Ⅱ detoxification enzyme genes and antioxidant enzyme genes.With high oxygen consumption and abundant polyunsaturated fatty acids,central nervous system is sensitive to oxidative stress.The role of Nrf2/ARE transduction pathway in the central nervous system is paid more and more attentions.This article summarizes the latest progress in research on regulatory mechanisms of Nrf2/ARE transduction pathway as well as its role in central nervous system diseases.

关 键 词：转录因子红细胞系-2p45相关因子 中枢神经系统 氧化应激 细胞保护 

分 类 号：Q507[生物学—生物化学] R741[医药卫生—神经病学与精神病学]