胸椎恶性血管球瘤临床病理观察  

Malignant glomus tumor of thoracic spine:a clinicopathological analysis

作　　者：魏清柱[1] 赵彤[2] 李绍林 刘江欢[1] 张志雄[1] 阳巧[1] 

机构地区：[1]南方医科大学第三附属医院病理科,广州510630 [2]南方医科大学南方医院病理科,广州510630 [3]南方医科大学第三附属医院影像科,广州510630

出　　处：《诊断病理学杂志》2011年第3期213-215,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨骨内恶性血管球瘤的临床病理特征。方法对1例胸椎恶性血管球瘤的临床表现、影像学、组织学特征、免疫组化结果进行分析,并文献复习。结果患者男性,60岁。胸背部疼痛2年。术前MRI提示胸8椎体病变。镜下肿物呈结节状,由玻璃样变性的纤维结缔组织分隔,肿瘤组织呈血窦样结构,血窦衬覆内皮细胞,窦间为数层肿瘤细胞,瘤细胞上皮样,胞界较清晰,胞质淡染,胞核大小不等,核分裂象少见。免疫组化示肿瘤细胞vimentin和SMA(+)。结论椎骨内恶性血管球瘤罕见,低度恶性,具有独特的病理形态学特征。Purpose To study the clinicopathologic characteristics of malignant glomus tumor in the thoracic spine.Methods The clinical manifestations,image,histological features and immunohistochemical results of a malignant glomus tumor were analyzed,with review of the related literatures.Results A 60-year-old man presented with a 2-year history of chest and back pain.MRI imaging study revealed a lesion at T-8.The epithelioid tumor cells arranged around sinus-like vascular channels lined by endothelial cells.The epithelioid tumor cells had lightly eosinophilic cytoplasm with well-demarcated borders,atypical nuclei and a few mitotic figures.Immunohistochemical study revealed positive staining for vimentin and SMA.Conclusion Spinal intraosseous malignant glomus tumor is a rare tumor with characteristic histopathological features and it should be regarded as low-grade malignant tumors.

关 键 词：恶性血管球瘤 脊椎 诊断 鉴别诊断 

分 类 号：R739.42[医药卫生—肿瘤]