乳腺癌MR灌注成像与肿瘤微血管密度的相关性研究  

Breast Cancer： Correlation of MR Perfusion-Weighted Imaging. with Tumor Angiogenesis

作　　者：胡文娟 王兰云 魏冉 谢蕴 潘玉林 张蓓[3] 

机构地区：[1]上海市瑞金医院集团闵行区中心医院放射科,上海201100 [2]上海市瑞金医院集团闵行区中心医院病理科,上海201100 [3]上海交通大学附属瑞金医院放射科

出　　处：《实用放射学杂志》2011年第6期886-889,共4页Journal of Practical Radiology

基　　金：上海市科学技术委员会科研计划项目（09411962800）.

摘　　要：目的探讨乳腺浸润性导管癌磁共振T2^＊W首次通过灌注成像与肿瘤血管生成间的相关关系。方法对26例乳腺浸润性导管癌患者行术前磁共振T2^＊W首次通过灌注成像，并对其手术标本进行免疫组织化学染色，计算其微血管密度，分析乳腺癌灌注成像参数与肿瘤微血管密度间的相关关系。结果26例浸润性导管癌T2^＊W首次通过灌注成像最大信号强度丢失率及T2^＊弛豫率（△R2^＊Peak）与肿瘤微血管密度间存在正相关关系（r=0．695，P=0．003；r=0．689，P—O．003）。结论T2^＊W首次通过灌注成像相关参数与肿瘤微血管密度正相关，可在一定程度上反映肿瘤血管生成情况。Objective To evaluate the correlation of MR T2^＊ weighted first-pass perfusion imaging（PWI）with microvessel density（MVD） in breast infiltrating duct carcinoma. Methods 26 patients with breast infiltrating duct carcinomas were prospectively studied using MR T2^＊ weighted first-pass perfusion imaging before surgery in our hospital from May 2009 to December 2009,all patients were proved by histopathology. Mierovessel density were estimated in 26 breast infiltrating duct carcinomas . Results The maximum signal intensity decrease ratio and the △R2 ^＊ peak of the breast infiltrating duct carcinomas were （45.5 ± 22.1） % and 4.24 ±0.38,a positive correlation between the maximum signal intensity decrease ratio and MVD was found in breast infiltrating duct carcinomas（r=0. 695,P=0. 0003〈0.01） and also between the △R2 ^＊ peak and MVD （r=0. 689,P=0. 003〈0.01）. Conclusion The T2 ^＊ weighted first-pass perfusion imaging features can reflect the expression level of MVD in breast carcinoma, based on which the tumor angiognensis can be inferred.

关 键 词：乳腺 乳腺癌 磁共振成像 微血管密度 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]