高危型人乳头瘤病毒检测对细胞学结果为意义不明的非典型鳞状细胞和低度鳞状上皮内病变的管理价值  

Management value of high-risk human papilloma virus detection in the women with atypical squamous cell of undetermined significance and low grade squamous intraepithelial lesion of thin prep liquid-based cytology

作　　者：张引民[1] 汪秀芹[1] 苗凤英[1] 邢海燕[1] 

机构地区：[1]山东省日照市人民医院妇科,276826

出　　处：《中国医师进修杂志》2011年第18期27-29,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨第二代杂交捕获试验（He一2）检测高危型人乳头瘤病毒（HR．HPV）DNA对细胞学结果为意义不明的非典型鳞状细胞（ASCUS）和低度鳞状上皮内病变（IJsIL）的管理价值。方法收集细胞学结果为ASCUS（178例）和LSIL（108例）的HR-HPV感染情况，以敏感度、特异度、阳性预测值和阴性预测值来评价He-2检测HR-HPVDNA在宫颈病变筛查中的价值。结果He-2检测HR-HPVDNA对于ASCUS中病理结果为宫颈上皮内瘤变（CIN）Ⅱ及其以上级别病变的敏感度为89．83％（53／59），特异度为53．78％（64／119），阳性预测值为49．07％（53／108），阴性预测值为91．43％（64／70）；对于LSIL中CINII及其以上级别病变的敏感度为97．62％（41／42），特异度为22．73％（15／66），阳性预测值为44．57％（41／92），阴性预测值为93．75％（15／16）。结论HR．HPVDNA检测是一种管理细胞学结果为ASCUS和LSIL病例的有效手段。Objective To discuss the significance of high-risk human papilloma virus （HR-HPV） detection by hybrid capture 2 （Hc-2） in managing the women with atypical squamous cell of undetermined significance （ASCUS） and low grade squamous intraepithelial lesion （LSIL） of thin prep liquid-based cytology （TCT）. Methods One hundred and seventy-eight women with ASCUS and 108 women with LSIL were studied. The infection of HR-HPV in the women was analyzed. And sensitivity, specificity, positive predictive value （ PPV ） and negative predictive value （ NPV ） were used to evaluate the significance of HR- HPV detection by Hc-2 in managing the women with ASCUS and LSIL of TCT. Results Sensitivity, specificity, PPV and NPV of HR-HPV DNA detection by Hc-2 in screening CIN Ⅱ or above in ASCUS were 89.83% （53/59）,53.78% （64/119）, 49.07% （53/108）, 91.43% （64/70） respectively,and in LSIL were 97.62%（41/42）,22.73%（15/66）, 44,57%（41/92）, 93.75%（15/16） respectively. Conclusion HR-HPV detection by He-2 is an effective measure in managing the women with ASCUS and LSIL of TCT.

关 键 词：人乳头瘤病毒 意义不明的非典型鳞状细胞 低度鳞状上皮内病变 

分 类 号：R737[医药卫生—肿瘤]