无抽搐电休克合并帕罗西汀治疗难治性强迫症的临床观察  

A clinical study of modified electroconvulsive therapy combined with paroxetine in the treatment of refractory obsessive-compulsive disorder

作　　者：刘严[1] 张华[1] 

机构地区：[1]胜利石油管理局胜利医院,山东东营257055

出　　处：《精神医学杂志》2011年第3期189-191,共3页Journal of Psychiatry

摘　　要：目的探讨无抽搐电休克(MECT)合并帕罗西汀治疗难治性强迫症的疗效和安全性。方法对62例难治性强迫症患者随机分为研究组和对照组各31例。前者给予无抽搐电休克合并帕罗西汀治疗,后者单用帕罗西汀治疗。观察8周,采用Yale-Brown强迫量表(Y-BOCS)、汉密尔顿抑郁量表(HAMD)评定疗效,用治疗中的症状量表TESS评定安全性。结果治疗后研究组的显效率为60.0%,对照组的显效率为25.8%,两组比较差异有统计学意义(P<0.05)。两组治疗后Y-BOCS、HAMD评分以研究组下降更明显(P<0.01),两组TESS评分差异无统计学意义(P>0.05)。结论无抽搐电休克合并帕罗西汀治疗难治性强迫症可提高疗效,安全性好。Objective To investigate the efficiency and safety of Modified Electroconvulsive Therapy （MECT） combined with paroxetine in the treatment of refractory obsessive - compulsive disorder （ROCD）. Methods A total of 62 patients with ROCD were randomized into study group （31 cases） treated with MECT combined with paroxetine for 8 weeks and control group （31 cases ） treated with paroxetine monotherapy for 8 weeks. Yale - Brown obsessive - Compulsive Scale （Y -BOCS） and Hamilton Depression Scale （HAMD） were used to assess the efficiency, and Treatment Emergent Symptoms Scale （TESS） was used to assess the safety of the treatment. Results Effective rate in study group was significantly higher than that in control group （60.0% vs. 25.8% ,P 〈 0.05 ）. Compared with control group, the scores of HAMD and Y - BOCS in study group decreased more obviously after the treatment （P 〈 0.01 ）. There was no significant difference in score of TESS between two groups （ P 〉 0.05 ）. Conclusion MECT combined with paroxetine is effective for refractory obsessive -compulsive disorder with satisfactory safety.

关 键 词：难治性强迫症 帕罗西汀 无抽搐电休克(MECT) 

分 类 号：R749.7[医药卫生—神经病学与精神病学]