放疗联合帕米膦酸二钠治疗多发骨转移癌的疗效观察  

The Clinical Observation of Metastatic Bone Tumors Treated with Radiotherapy Combined with Pamidronate

作　　者：汪志求[1] 

机构地区：[1]安徽省安庆市立医院肿瘤内科,安徽安庆246001

出　　处：《河北医学》2011年第7期865-868,共4页Hebei Medicine

摘　　要：目的:观察放疗联合帕米膦酸二钠治疗骨转移癌疼痛的疗效。方法:48例骨转移癌性疼痛的病人,分为两组。放疗联合帕米膦酸二钠组(联合组)24例;单纯放疗组(单放组)24例。放射治疗剂量为DT 3000cGy/10 f,两组相同;帕米膦酸二钠为90mg静滴,时间大于6h,每三周重复,至少两次。结果:放疗结束后两组疼痛缓解率分别为85%,80%,无统计学差异;随访8周后疼痛缓解率分别为79.17%,62.5%,P>0.05,无统计学差异;2月后KPS评分改善两组有效率分别为70.8%,50%。未发现严重放疗反应及药物毒性反应。结论:放疗或放疗联合帕米膦酸二钠治疗骨多发转移癌均能取得满意疗效,但放疗联合帕米膦酸二钠治疗疗效可能更优,且未见严重不良反应。Objective ： To evaluate the efficacy of radiotherapy combined pamidronate for bone metasta- ses from cancer. Method： Forty-eight patients were randomized into two groups. Twenty-four patients received radiotherapy plus pamidronate. Twenty-four patients received radiotherapy. The total tumor dose of each groups was 3000cGy/lOf; pamidronate 90rag iv, more than 6h. The cycle was repeated every 21days,at least two cycles. Result： The pain relief rate was 85% and 80% respectively after radiotherapy in different groups. There was no significant difference in both groups; The pain relief rate was 79.17% and 62.5% after 8 weeks, follow up;P〉0.05. The side effect was mild. Conclusion： Radiotherapy or radiotherapy combined with pamidronate is effective in the treatment of metastatic bone tumors . Radiotherapy combined with pamidronate could be more effective than radiotherapy , and there is no significant side effect .

关 键 词：放疗 帕米膦酸二钠 骨转移癌 

分 类 号：R738.1[医药卫生—肿瘤]