乳腺癌癌细胞器形态参数的定量分析  

A Fixed Amount Research About the Cancer Cell's organelles in Breast Carcinoma

作　　者：宋精玲[1] 李亚芳[2] 王爱敏[2] 林萍[1] 魏万里[3] 刘美玉[2] 

机构地区：[1]昆明医学院电子显微镜室,昆明650031 [2]昆明医学院海源学院物理数学教研室 [3]昆明医学院第三附属医院

出　　处：《数理医药学杂志》2011年第3期276-278,共3页Journal of Mathematical Medicine

基　　金：云南省教育厅科学研究基金项目(JYT0904H)

摘　　要：用体视学方法分别对20例中期和20例晚期女性乳腺浸润性硬性单纯癌的四种癌细胞细胞器的23个形态参数进行测定和分析,并用t值检验方法筛选出区别度最高的7个最佳参数及有显著差异的9个形态参数。研究发现最突出的是晚期癌与正常组比较线粒体的3种膜的比表面明显下降,而体积明显增大。同时,还提示了中期癌与晚期癌比较,游离核糖体在晚期比表面Sr2及面密度Svr2均明显增大。Stereological method was applied to measure and analyze 23 morphological parameters of four kinds of cancer cell＇s organelles.The cases include 20 cases of female mid-invasive breast cancer and 20 cases of female advanced breast cancer.t test was used to obtain 7 best parameters and 9 morphological parameters of significant difference.The result showed that compared with normal cell,the three kinds mitochondrial membrane＇s specific surface of the cancer cells were obviously decreased while volume increased significantly in the late stage breast carcinoma.Synchronously,compared with mid-term cancer and advanced cancer,free ribosome＇s specific surface Sr2 and surface density Svr2 all obviously increased in the late stage in breast carcinoma.

关 键 词：体视学 乳腺癌 线粒体 溶酶体 粗面内质网 核糖体 

分 类 号：R737.9[医药卫生—肿瘤] Q271[医药卫生—临床医学]