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作 者:周振和[1] 王军[1] 陈琳[1] 王志强[1] 程灶火[1]
机构地区:[1]南京医科大学附属无锡精神卫生中心临床心理科,南京214151
出 处:《中华行为医学与脑科学杂志》2011年第6期507-509,共3页Chinese Journal of Behavioral Medicine and Brain Science
基 金:江苏省卫生厅医学科研面上课题(H201043)
摘 要:目的探讨艾司西酞普兰对惊恐障碍患者情绪图片信息认知偏倚的影响。方法选择符合CCMD-3惊恐障碍诊断标准的30例患者作为试验组,与试验组匹配性别、年龄的30例健康人作为对照组。实验组予艾斯西酞普兰治疗8周。两组分别在治疗前以及8周后予情绪图片刺激的点探测任务检测,比较治疗前以及8周后反应时以及注意偏向分差别。结果试验组8周后汉密顿焦虑量表评分[(7.81±2.52)分]明显低于治疗前[(17.23±3.12)分](P=0.002)。重复测量ANOVA显示,探测位置主效应显著[F(1,58)=4.34,P=0.031],异侧位置的反应时长于同侧位置;情绪面孔图片类型与组间水平交互作用显著[F(1,58)=19.21,P=0.000];探测位置与组问水平交互作用显著[F(1,58)=16.15,P=0.000];情绪面孔图片类型与探测位置交互作用显著[F(1,58)=9.25,P=0.015];情绪面孔图片类型×探测位置×组问水平交互作用显著[F(1,58)=7.31,P=0.002],LSD比较显示试验组对恐惧面孔图片异侧位置的反应时长于同侧位置(P=0.0009)。试验组治疗8周后对恐惧面孔图片反应时以及注意偏向分明显低于治疗前(P=0.032,0.008)。结论惊恐障碍患者对恐惧面孔图片信息表现出认知偏倚,艾斯西酞普兰可能具有改善认知偏倚的作用。Objective To investigate the effect of escitalopram treatment on cognitive bias to the emotional facial information in patients with panic disorder. Methods 30 patients met CCMD-3 criteria for panic disorder were enrolled as research group and marched sexual and age 30 healthy persons enrolled as control group. Patients were treated with escitalopram for 8 weeks. All participants measured with dot-probe task of emotional facial information at base and after 8 weeks. RTs and attentional bias scores were compared respectively. Results After 8 weeks,HAMA scores (7.81 ±2.52 ) in research group were lower than that of at base (17.23 ±3. 12) (P = 0. 002). A repeated measure ANOVA revealed a significant probe site main effect (F(1,58) =4.34, P = 0.031 ), RTs of antarafacial site were longer than that of homonymy site. It revealed a significant probe site and group interaction (F(1,58) = 16. 15, P =0. 000) ,a significant emotional facial information type and probe site interaction(F(l,58〉 =9. 25, P =0.015) ,and a significant emotional facial information type × probe site x group interaction(F(1,58) =7.31, P= 0.002). LSD test showed that RTs of antarafacial site to fear facial information in research group were longer than that of homonymy site(P=0. 0009). RTs and attention bias scores of antarafacial site to fear facial information after 8 weeks in research group were lower than that of at base(P = 0. 032 ,0. 008 ). Conclusion Patients with panic disorder have the cognitive bias to the fear facial emotional stimulus, and escitalopram treatment might improve the cognitive bias.
关 键 词:惊恐障碍 情绪面孔图片 点探测任务 认知偏倚 艾斯西酞普兰
分 类 号:R749.7[医药卫生—神经病学与精神病学]
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