老年急性髓系白血病治疗的研究进展  

Review on acute myeloid leukaemia therapy in the elderly

作　　者：周慧[1] 王建虹[1] 闵捷[1] 

机构地区：[1]山东大学附属省立医院血液科,山东济南250021

出　　处：《中华肿瘤防治杂志》2011年第10期816-820,共5页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:总结国内外老年急性髓系白血病(AML)的治疗现状,探讨传统化疗、造血干细胞移植及新药在老年AML治疗中的应用。方法:应用Med-line及PubMed全文数据库检索系统,以"老年、急性髓系白血病、治疗"等为关键词,检索2004-01-2011-06的相关文献。纳入标准:1)传统化疗在老年AML治疗中应用;2)老年AML造血干细胞移植;3)新药对老年AML治疗的影响。符合要求并纳入分析的文献39篇。结果:对于高强度的化疗方案,部分患者可以耐受并获得良好的治疗效果,但是部分患者接受低剂量的化疗效果更佳;异基因造血干细胞移植为老年AML提供了治愈的可能性;一系列新药的出现为治疗窗窄、耐受性差的老年AML患者提供了新的治疗方法。结论:老年AML患者对化疗药物的治疗反应及耐受性差,应选择合适的诱导缓解及巩固治疗方案。OBJECTIVE： To summarize the advances of acute myeloid leukaemia （AML） therapy in the elderly and discuss clinical outcomes of traditional chemotherapy, allogeneic stem cell transplantation and some novel agents in the older AML patients therapy. METHODS： The fulltext database retrieval system of retrievaling Medline and Pubmed were searched. The words ＂old age, AML, therapy＂ were used as key words, to retrieval the literature about the AML therapy in the elderly from January 2004 to June 2011. Including standards： 1） traditional chemotherapy in the treatment of AML in the elderly; 2） stem cell transplantation in the treatment of older patients with AML; 3）the effects of some novel agents in older AML patients therapy. At last, 39 papers were selected and analyzed. RESULTS： Some patients tolerate and benefit from intensive remission-induction approaches, while others are best managed with less aggressive strategies. Allogeneie stem cell transplantation as consolidation therapy is a potentially curative option. The appearance of some novel agents privides new approaches to older AML patients, with their narrow therapeutic window and poor tolerance, are well positioned to derive a benefit from these novel agents. CONCLUSION： Because of decreased susceptibility to chemotherapy and poor tolerance for toxicity, it is very important to select the appropriate therapy to maximize the therapeutic benefit and minimize toxicity in the older AML patients.

关 键 词：白血病 髓样 急性/治疗 综述文献 老年人 

分 类 号：R733.72[医药卫生—肿瘤]