Richter综合征一例报告并文献复习  

Richter's syndrome:A case report and literature review

作　　者：何合胜[1] 李光曦[1] 黄东平[1] 

机构地区：[1]皖南医学院附属弋矶山医院血液科,安徽芜湖241001

出　　处：《中华肿瘤防治杂志》2011年第8期628-630,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为了探讨Richter综合征的临床病理特点、诊断、治疗与预后,报道1例经典型Richter综合征,通过临床表现、骨髓细胞学、淋巴结病理及免疫组化研究该病的特点,并复习有关文献。结果患者外周血及骨髓见大量成熟小淋巴细胞,细胞形态学符合慢性淋巴细胞白血病骨髓像,骨髓细胞免疫表型为CD5(+)、CD10(-)、CD19(+)、CD20(+)、CD23(+)和CD38(+);淋巴结组织病理学为弥漫性大B细胞淋巴瘤。经多周期化疗,疗效欠佳,仅生存11个月。初步研究结果提示,该例患者初诊时为慢性淋巴细胞白血病同时合并弥漫性大B细胞淋巴瘤,符合经典型Richter综合征特点,国内罕见,生存期短,预后很差。The objective of this study was to explore clinical and pathological characteristics, diagnosis, treatrnent and prognosis of Richter＇s syndrome. The clinical and laboratory feather of one case classic Richter＇s syndrome was reported,and the related literature was reviewed. A large number of mature small lymphocytes were found in pe ripheral blood and bone marrow,the cellular morphology was consistent with chronic lymphocytic leukemia, immuno logical phenotype of bone marrow was CD5 （ ＋ ）, CD10 （ - ）, CD19 （ ＋ ）, CD20 （ ＋ ）, CD23 （ ＋ ） and CD38 （ ＋ ）. Lymph node biopsy was diaglosed as diffuse large B cell lymphoma, The patient died within 11 months after multiple courses of chemotherapy. In conclusion, Newly diagnosed patient with chronic lymphocytic leukemia complicated with diffuse large B cell lymphoma is in line with classic Richter＇s syndrome. Richter＇s syndrome rarely occurs in China with poor prognosis and short survival expectance.

关 键 词：淋巴瘤 非霍奇金 白血病 淋巴细胞 慢性 综合征 病例报告[文献类型] 

分 类 号：R733.1[医药卫生—肿瘤]