肺癌患者血清NTx、ICTP和BAP水平与骨转移的相关性研究  

Relationships between the levels of serum NTx,ICTP,BAP and bone metastasis in patients with lung cancer

作　　者：张世强[1] 陈冬波[1] 王保庆[1] 张兰胜[1] 

机构地区：[1]徐州医学院第二附属医院肿瘤内科,江苏徐州221006

出　　处：《临床肿瘤学杂志》2011年第6期534-537,共4页Chinese Clinical Oncology

摘　　要：目的探讨联合检测骨代谢生化指标血清Ⅰ型胶原氨基末端肽(NTx)、Ⅰ型胶原羧基端肽(ICTP)及骨特异性碱性磷酸酶(BAP)对诊断肺癌骨转移的临床意义。方法选择经细胞学和病理学确诊的肺癌患者106例,分为两组,其中骨转移组61例,无骨转移组45例。用ELISA法检测两组患者血清NTx、ICTP及BAP浓度。结果骨转移组患者血清NTx、ICTP及BAP水平分别为(25.36±11.07)nmol/L、(29.18±10.74)μg/L和(78.31±16.53)μg/L,明显高于无骨转移组的(12.16±7.62)nmol/L、(11.02±5.32)μg/L和(24.01±7.98)μg/L,差异具有统计学意义(P<0.01);NTx、BAP、ICTP诊断骨转移的灵敏度和特异度分别为90.16%和84.44%、80.32%和77.78%、70.49%和91.11%;多发骨转移组患者血清NTx、ICTP及BAP水平明显高于单发骨转移组(P<0.05);骨转移组患者血清NTx、ICTP及BAP水平与疼痛程度呈正相关;不同性别、病理类型、转移部位患者的血清NTx、ICTP及BAP水平差异无显著性(P>0.05)。结论血清NTx、ICTP及BAP水平对肺癌骨转移诊断的灵敏度和特异度较高,与骨转移数目和疼痛程度相关,是诊断肺癌骨转移的重要参考指标。Objective To study the clinical significance of serum N-telopeptide of type I collagen（NTx）,carboxy-terminal collagen telopeptide（ICTP）,and bone-specific alkaline phosphatase（BAP） in diagnosing bone metastasis of lung cancer.Methods A total of 106 patients with lung cancer were diagnosed by pathology in this study.Patients were divided into two groups： 61 patients with bone metastasis and 45 patients without bone metastasis.The levels of serum NTx,ICTP and BAP were measured by ELISA.Results The levels of serum NTx,ICTP and BAP in bone metastasis group were（25.36±11.07）nmol/L,（29.18±10.74）μg/L and（78.31±16.53）μg/L higher than（12.16±7.62）nmol/L,（11.02±5.32）μg/L and（24.01±7.98）μg/L in non-bone metastasis group（P0.01）.The sensitivity and specificity of serum NTx in the diagnosis of bone metastasis were 90.16% and 84.44%,respectively.The sensitivity and specificity of serum BAP were 80.32% and 77.78%,respectively.The sensitivity and specificity of serum ICTP were 70.49% and 91.11%,respectively.While The levels of serum NTx,ICTP and BAP in patients with more bone metastasis were significantly higher than those in single bone metastasis（P0.05）.The levels of serum NTx,ICTP and BAP were related to the degree of pain with bone metastasis.But we could not find that there were difference of serum NTx,ICTP and BAP among sex,pathology and different bone metastasis position.Conclusion The sensitivity and specificity of the serum NTx,ICTP and BAP are higher in diagnosis of lung cancer with bone metastasis.The three markers can be regarded as important factors for bone metastasis of lung cancer.

关 键 词：Ⅰ型胶原氨基末端肽 Ⅰ型胶原羧基端肽 骨特异性碱性磷酸酶 肺癌 骨转移 

分 类 号：R734.2[医药卫生—肿瘤]