腹腔镜直肠癌根治术对患者血清C反应蛋白的影响  

Change of C-reactive protein in patients with colorectal cancer treated by laparoscopic radical operation

作　　者：周志涛[1] 李俊[1] 吕培标 毛常青 伍联华 钟国英[1] 王存川[2] 

机构地区：[1]广东省梅县人民医院普外科,广东梅县514011 [2]暨南大学第一附属医院微创外科中心,广东广州510630

出　　处：《海南医学院学报》2011年第7期945-947,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020110239)~~

摘　　要：目的:探讨腹腔镜直肠癌手术对患者血清C反应蛋白(CRP)的影响。方法:70例患者随机分为腹腔镜直肠癌根治术(腹腔镜组)和开腹直肠癌根治术(开腹组),术前1 d和术后1、3、57、d采用酶联免疫吸附双抗体夹心(ELISA)法测定血清中CRP水平,观察术中出血量、淋巴结数、肠动力恢复时间及手术并发症等情况。结果:腹腔镜组术中出血量、术后并发症发生率和肠道功能恢复时间均显著低于开腹组,差异有统计学意义(P<0.05);两组均无阳性切缘,淋巴结清扫数比较差异无统计学意义(P>0.05);术前1 d两组CRP水平比较无显著性差异(P>0.05),术后1、3、5、7 d开腹组CRP水平显著高于腹腔镜组,差异有统计学意义(P<0.05)。结论:腹腔镜直肠癌根治术对机体的创伤小、患者急性炎症反应轻,有利于患者术后恢复。Objective： To investigate the effects of laparoscopic radical operation on C-reactive protein（CRP） in patients with colorectal cancer.Methods： A total of 70 patients with colorectal cancer were divided into laparoscopic radical operation（laparoscope group） and conventional open radical operation（laparotomy group）.The serum CRP was detected by ELISA on 1st day before surgery and 1st,3th,4th,7th day after surgery.The blood loss,number of lymph nodes,gastrointestinal motility recovery time and complications were observed.Results： The blood loss,postoperative complication and gastrointestinal motility recovery time were significantly lower than those of laparotomy group,and differences between two groups were significant（P〈0.05）.There were no positive surgical margins in the two groups,and no significant difference in number of lymph nodes between two groups（P〉 0.05）.On the 1st day before surgery,there was no significant difference in CRP level（P〉 0.05）,but on the 1st,3th,4th,7th day after surgery,the CRP level of laparotomy group was significantly higher than the laparoscope group（P〈0.05）.Conclusion： The laparoscopic radical operation on the body with colorectal cancer has fewer traumas.The acute inflammatory response is mild and good for postoperative recovery.

关 键 词：腹腔镜 直肠肿瘤 C反应蛋白 

分 类 号：R735.37[医药卫生—肿瘤]