脑梗死合并代谢综合征患者脂联素水平与脑动脉狭窄的相关性  

Relationship Between Adiponectin,Metabolic Abnormalities and Cerebral Artery Atherosclerotic Stenosis in Patients with Acute Cerebral Infarction Complicated by Metabolic Syndrome

作　　者：朱立勋[1] 丁素菊[1] 

机构地区：[1]第二军医大学附属长海医院神经内科,上海市200433

出　　处：《中国动脉硬化杂志》2011年第8期684-687,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨脑梗死合并代谢综合征患者脂联素水平与脑动脉狭窄的相关性。方法对74例因急性脑梗死入院的患者,根据国际糖尿病联盟代谢综合征诊断标准,分为代谢综合征组及非代谢综合征组。检测血清脂联素、高密度脂蛋白、低密度脂蛋白、甘油三酯及总胆固醇,借助核磁共振血管成像明确有无颅内外动脉粥样硬化狭窄,计算各组的发生率。结果代谢综合征组血清脂联素水平显著低于非代谢综合征组(2.759 mg/L比3.538 mg/L,P<0.05)。代谢综合征组血管狭窄发生率(85.0%)显著高于非代谢综合征组(64.7%),差异有统计学意义(P=0.039)。单因素Logistic回归分析表明脂联素与脑动脉硬化狭窄无显著相关性(OR=1.272,P>0.05),代谢综合征与动脉粥样硬化狭窄呈正相关(OR=3.09,P<0.05)。结论脂联素水平下降是代谢综合征发病原因之一;代谢综合征与脑动脉粥样硬化狭窄相关;脂联素与脑动脉狭窄无明显相关性。Aim To investigate the relationship between adiponectin,metabolic abnormalities and cerebral artery atherosclerotic stenosis in patients with acute cerebral infarction complicated by metabolic syndrome（MS）. Methods 74 patients with acute ischemic stroke were studied who were hospitalized.All subjects were divided into MS group and non-MS group with the criteria of MS published by international diabetes federation（IDF）.All patients underwent magnetic resonance angiography（MRA） to measure the intra-and extra-cranial atherosclerotic stenosis and reveal the incidences of stenosis.The values of plasma adiponectin were detected for all patients too. Results The frequency of cerebral arterial stenosis in patients with acute cerebral infarction in MS group and non-MS group were 85.0% and 64.7%,respectively,and there was statistical significance between the two groups（P=0.039）.The patients with acute cerebral infarction complicated by MS showed lower levels of plasma adiponectin and higher values of serum triglyceride and the levels of serum total cholesterol（P0.05）,low-density lipoprotein cholesterol and high-density lipoprotein cholesterol had no significant difference compared with the non-MS group（P0.05）.The result of Logistic regression analysis indicated that MS was associated with atherosclerotic stenosis（OR=3.09,P0.05）and the presense of plasma adiponectin was not the risk factor for cerebrovascular stenosis（OR=1.272,P0.05）. Conclusion The decrease of the levels of plasma adiponectin induced MS and was the cause of metabolic abnormalities.MS was associated with atherosclerotic stenosis.The values of plasma adiponectin was not significantly associated with atherosclerotic stenosis.

关 键 词：脂联素 代谢综合征 急性脑梗死 脑动脉粥样硬化性狭窄 

分 类 号：R741[医药卫生—神经病学与精神病学]