肝脂酶基因-250G/A多态性与腔隙性脑梗死的关系  

The Relationship between Polymorphism of Hepatic Lipase Gene-250G/A Polymorphism and Lacunar Infarction

作　　者：陈李芳[1] 谭利明[2] 肖志杰[2] 聂赛[3] 谢湘竹[3] 韩漫夫[1] 

机构地区：[1]广东省深圳市第二人民医院神经内科,广东省深圳市518035 [2]中南大学湘雅二医院神经内科,湖南省长沙市410011 [3]中南大学湘雅二医院心内科,湖南省长沙市410011

出　　处：《中国动脉硬化杂志》2011年第8期688-692,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨肝脂酶基因(LIPC)-250G/A多态性与腔隙性脑梗死的关系。方法采用病例对照研究,筛选152名腔隙性脑梗死患者及108名正常对照组人群为研究对象。采用聚合酶链反应-单核苷酸多态性方法测定LIPC-250G/A基因多态性。结果在腔隙性脑梗死人群中,LIPC-250G/A基因型分布为GG 51.32%、GA 36.84%和AA 11.84%,等位基因G和A的分布频率分别为0.697和0.303。GA型和AA型的血浆高密度脂蛋白胆固醇水平显著高于GG型(P<0.05)。LIPC-250G/A基因型和等位基因频率分布在腔隙性脑梗死组与对照组中之间差异无显著性(P>0.05)。结论 LIPC-250G/A多态性产生有益的临床血脂谱,但可能与腔隙性脑梗死发病无关。Aim To explore the relationship between hepatic lipase gene（LIPC）-250G/A polymorphism and lacunar infarction（LI）. Methods A case-control study was performed in 152 patients with LI and 108 healthy controls.The polymerase chain reaction-single nucleotide polymorphism（PCR-SNP） was used to determine the LIPC-250G/A polymorphism. Results The LIPC-250G/A genotype distribution in patients with LI was GG 51.32%,GA 36.84% and AA 11.84%,respectively.Allele frequencies for G and A were 0.697 and 0.303 respectively.The serum high density lipoprotein cholesterol（HDL-C） level of the GA and AA genotypes were significantly higher than the GG genotype（P0.05）.There were no differences in the distribution of genotypes and alleles of LIPC-250G/A Polymorphism between patients and their counterparts（P0.05）. Conclusion The LIPC-250G/A polymorphism results in a beneficial profile of blood lipids,while it may not be associated with LI.

关 键 词：肝脂酶 基因 多态性 单核苷酸 腔隙性脑梗塞 

分 类 号：R743[医药卫生—神经病学与精神病学]