1286例先天性心脏病患儿致病因素的调查研究  

Investigation on the Risk Factorsfor 1286 Cases of Congenital Heart Diseases

作　　者：仇小强[1] 覃益敏[1] 谢晓宇[1] 刘芮荣 潘南海[1] 彭如宽[1] 张志勇[1] 梁秋萍[1] 

机构地区：[1]广西医科大学公共卫生学院计算机教研室,南宁530021

出　　处：《同济医科大学学报》1999年第5期399-401,共3页Acta Universitatis Medicinae Tongji

基　　金：广西壮族自治区科委青年科学基金

摘　　要：采用病例对照研究方法， 对广西５个地级市及郊区１２８６ 例先天性心脏病患儿和对照组进行流行病学调查，所得资料在单因素分析的基础上， 用条件ｌｏｇｉｓｔｉｃ回归模型进行多因素综合分析， 筛选与儿童先天性心脏病发病关系密切的危险因素。分析结果表明， 母亲孕期年龄偏大 （ＯＲ＝ ５．２２）、父亲饮酒 （ＯＲ＝ ２．１２）、母亲孕早期服用阿司匹林（ＯＲ＝ ４．４５）、服四环素类药物 （ＯＲ＝ ２．８９）、服避孕药（ＯＲ＝ ５．５８）、接触化学毒物（ＯＲ＝ ７．６０）、罹患风疹（ＯＲ＝２．２３） 和感冒 （ＯＲ＝ ８．２１） ８A case-control study w as carried out to investigate the risk factors for 1286 cases of congenital heart diseases and their controls in 5 cities and suburbs of Guangxi province.Based on the single-factoranalysis, conditionalLogistic m odelw asused to perform the m ulti-factors syntheticalanalysis on the data obtained to screen the risk factors closely associated w ith the occurrence of congenital heart diseases. The results show ed that the follow ing 8 factors w ere related w ith the occurrence of congenital heart diseases: older m other (OR= 5.22), father's drinking (OR= 2.12), adm inistration of aspirin (OR = 4.55), of tetracycline (OR= 2.89) and of drug for contraception (OR= 5.58), exposure to chem ical toxic substances (OR= 7.60), suffering from urticaria (OR= 2.23) and com m on cold (OR= 8.21) in the early stage ofpregnancy.

关 键 词：儿童 先天性心脏病 危险因素 调查研究 

分 类 号：R725.411[医药卫生—儿科]