Wnt信号转导通路与肝纤维化关系的研究现况  

Relationship between the Wnt signaling pathway and liver fibrosis: recent research status

作　　者：万赞燕[1] 胡国信[1] 

机构地区：[1]南昌大学第一附属医院感染科,江西省南昌市330006

出　　处：《世界华人消化杂志》2011年第17期1761-1766,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30760230~~

摘　　要：Wnt信号转导通路是近年来分子生物学、细胞生物学和肿瘤研究中的一大热点,其参与调控细胞分化、癌变、凋亡及机体免疫、应激等多种病理生理过程.目前许多关于癌症方面的研究均已证实,阻断Wnt信号通路可以诱导癌症细胞的凋亡.肝纤维化的发生与多种信号通路的激活相关,有研究证实Wnt信号通路也参与了肝纤维化的发生,阻断该通路可以抑制HSC增殖及诱导其凋亡.HSC的活化作为肝纤维化发生的关键环节,通过诱导其凋亡有可能成为一种新的肝纤维化治疗方法.研究Wnt信号通路与肝纤维化关系为将来临床应用提供一定的理论基础.The Wnt signaling pathway participates in many physiological and pathological processes such as cell differentiation, carcinogenesis, apoptosis, immunity, and stress. Many studies have shown that blockage of the Wnt signaling pathway can induce cancer cell apoptosis. Many signaling pathways are associated with the pathogenesis of liver fibrosis. Several studies have shown that the Wnt signaling pathway is involved in the formation of liver fibrosis. Blockage of the Wnt signaling pathway could inhibit the proliferation and induce the apoptosis of hepatic stellate cell （HSC）. Since the activation of HSC plays a key role in the pathogenesis of liver fibrosis, induction of HSC apoptosis represents a new strategy for treating the disease. Elucidation of the relationship between the Wnt signaling pathway and liver fibrosis will certainly provide a theoretical basis for clinical treatment of the disease.

关 键 词：WNT信号转导通路 肝星状细胞 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统]