复方斑蝥胶囊对肝癌患者TACE治疗前后细胞免疫功能的影响  

Fufang Banmao Capsules improve immunological status in patients with hepatocellular carcinoma before and after transcatheter arterial chemoembolization

作　　者：殷飞[1] 李进军[1] 曹凤[1] 姚树坤[2] 

机构地区：[1]河北医科大学第四医院消化内科,河北省石家庄市050011 [2]卫生部中日友好医院,北京市100029

出　　处：《世界华人消化杂志》2011年第17期1843-1846,共4页World Chinese Journal of Digestology

基　　金：河北省科技厅科技攻关计划基金资助项目;No.05276101D-63~~

摘　　要：目的:探讨原发性肝癌(HCC)患者肝动脉插管化疗栓塞术(TACE)治疗前后及TACE后应用中成药复方斑蝥胶囊后细胞免疫功能变化.方法:所有HCC患者TACE治疗前及治疗后1wk、1mo,服用复方斑蝥胶囊前及用药后4wk用检测外周血T淋巴细胞亚群、NK细胞及ALT、AST、TBIL.结果:HCC患者与健康对照者相比CD4+淋巴细胞、NK细胞显著降低(P<0.05);CD8+淋巴细胞明显升高(P<0.05).TACE治疗后1wk及1mo均较TACE治疗前CD4+淋巴细胞、NK细胞均显著升高(33.1±7.5,38.9±7.8vs27.1±5.6;15.9±3.7,17.9±5.3vs10.6±4.7,均P<0.05),CD8+淋巴细胞显著降低(29.9±3.2,28.7±6.5vs34.8±5.6,均P<0.05);TACE治疗后服用复方斑蝥胶囊1mo与TACE治疗前比较,CD4+淋巴细胞和NK淋巴细胞显著增高(42.0±8.4vs27.8±5.8;21.2±3.6vs10.0±3.7,均P<0.05),CD8+淋巴细胞显著降低(26.7±3.4vs36.7±5.7,P<0.05).TACE治疗后1mo服用复方斑蝥胶囊组较未服用复方斑蝥胶囊组CD4+淋巴细胞、NK细胞均显著升高(P<0.05),CD8+淋巴细胞有降低趋势,但无统计学差异.结论:HCC患者抗肿瘤细胞免疫功能低下.HCC患者TACE治疗可使受抑制的细胞免疫功能部分恢复,服用中成药复方斑蝥胶囊后细胞免疫功能进一步提高.AIM： To investigate the impact of the traditional Chinese medicine Fufang Banmao Capsules on immunological status in patients with hepatocellular carcinoma （HCC） before and after transcatheter arterial chemoembolization （TACE）. METHODS： Fufang Banmao Capsules were administered to HCC patients before TACE or 1 wk or 1 mo after TACE. The proportions of CD4＋ and CD8＋ cell subsets, NK cells, and serum levels of ALT, AST, TBIL were measured 4 week after treatment. RESULTS： The proportions of CD4＋ and NK cells were lower and that of CD8＋ cells was higher in HCC patients than in healthy persons （both P 0.05）. After 1 wk or 1 mo of TACE therapy, the proportions of CD4＋ and NK cells were increased （33.1 ± 7.5, 38.9 ± 7.8 vs 27.1 ± 5.6; 15.9 ± 3.7, 17.9 ± 5.3 vs 10.6 ± 4.7, all P 0.05） and those of CD8＋ cells were decreased （29.9 ± 3.2, 28.7 ± 6.5 vs 34.8 ± 5.6, both P 0.05） compared to pretreatment values. The proportions of CD4＋ and NK cells were significantly higher and that of CD8＋ cells was significantly lower in patients treated with Fufang Banmao Capsules for 1 month after TACE therapy than in those not receiving Fufang Banmao Capsules after TACE therapy （all P 0.05）. CONCLUSION： The cellular immunological functions were inhibited in patients with HCC. TACE could reverse the immune suppression state in patients with HCC. The combination of TACE and Fufang Banmao Capsules could remarkably improve immunological functions in HCC patients.

关 键 词：原发性肝癌 肝动脉插管介入栓塞术 T淋巴细胞亚群 复方斑蝥胶囊 

分 类 号：R735.7[医药卫生—肿瘤]