DNA修复基因XRCC3 Thr241Met多态性与结直肠癌易感的Meta分析  

Association between DNA repair gene XRCC3 Thr241 Met single nucleotide polymorphisms and colorectal cancer susceptibility: a meta-analysis

作　　者：梁天伟[1] 孙轶[1] 卢永刚[1] 

机构地区：[1]南方医科大学附属柳州医院普外一科,广西壮族自治区柳州市545007

出　　处：《世界华人消化杂志》2011年第17期1855-1859,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨DNA修复基因X线修复交叉互补因子3(XRCC3)Thr241Met单核苷酸多态性与结直肠癌易感性的关系.方法:检索EMBASE(1974/2010-11)、PubMed(1966/2010-11)、中国期刊全文数据库CNKI(1994/2010-11)、中国生物医学文献数据库CBM(1978/2010-11)公开发表的DNA修复基因XRCC3Thr241Met单核苷酸多态性与结直肠癌易感性关系的研究.病例组及对照组XRCC3Thr241Met等位基因分布的优势比(OR)为效应指标,根据异质性检验结果,选择随机效应模型或固定效应模型对OR进行合并,同时进行偏倚评估.结果:共查到符合要求的文献9篇,病例组3294例,对照组3947例.分析结果显示:XRCC3Thr241Met点突变纯合子(Met/Met)患结直肠癌的风险与野生型纯合子(Thr/Thr)相比差异显著(OR=1.30,95%CI:0.86-1.98,P=0.22);显性模式下,XRCC3Thr241Met位点突变个体(突变纯合子+突变杂合子)(Met/Met)+(Met/Thr)患结直肠癌的风险与野生型纯合子(Thr/Thr)相比差异不显著(OR=1.05,95%CI:0.67-1.66,P=0.83);隐性模式下,XRCC3Thr241Met位点突变纯合子(Met/Met)患结直肠癌的风险与野生型(纯合子+杂合子)(Thr/Thr)+(Thr/Met)相比差异显著(OR=1.45,95%CI:0.94-2.25,P=0.09).结论:DNA修复基因XRCC3Thr241Met位点单核苷酸多态性与结直肠癌易感性间存不在明显相关性.AIM： To evaluate the association between single nucleotide polymorphisms of the X-ray repair cross-complementing group 3 （XRCC3） gene and colorectal cancer susceptibility. METHODS： By searching EMBSE （1974-2010.11）, Pubmed （1966-2010.11）, CNKI （1994-2010.11） and CBM （1978-2010.11）, We collected studies evaluating the association between XRCC3 gene polymorphisms and colorectal cancer susceptibility. The effect size was odds ratios （OR） of variant allele of XRCC3Thr241Met in the case and control groups. Random or fixed effect model was selected according to the results of heterogeneity test. The OR and publication bias were calculated using Review Manager 5.0 and STATA11.0 software. RESULTS： Nine case-control studies involving 3 294 cases and 3 947 controls were included. In the Met/Met versus Thr/Thr group, the odds ratio was 1.30 （95%CI： 0.86-1.98, P = 0.22）. For the dominant genetic model, the OR in the Met/ Met＋Met/Thr versus Thr/Thr group was 1.05 （95%CI： 0.67-1.66 P = 0.83）. For the recessive genetic model, the OR in the Met/Met versus Thr/ Thr＋Thr/Met group was 1.45 （95%CI： 0.94-2.25, P = 0.09）. CONCLUSION： There was no close association between XRCC3 Thr241 Met single nucleotide polymorphisms and colorectal cancer susceptibility.

关 键 词：结直肠癌 X线修复交叉互补因子3 单核苷酸多态性 META分析 

分 类 号：R735.3[医药卫生—肿瘤]