实验性肝硬化门静脉血流动力学与血液流变学的关系  

Relationship Between Portal Hemodynamics and Hemorrheology in Experimental Liver Cirrhosis

作　　者：王先明[1] 文明星[2] 房献平[2] 陈显玉[2] 

机构地区：[1]广东省深圳市红十字会医院,深圳518029 [2]湖南医科大学第二附属医院,长沙410011

出　　处：《湖南医学》1999年第5期321-323,共3页Hunan Medical Journal

摘　　要：【目的】探讨肝硬化时 ,血液流变学和血流动力学在门静脉高压症形成中的意义。【方法】对肝硬化大鼠不同时期门静脉血流动力学和血液流变学参数进行监测。【结果】肝硬化时大鼠血液流变学指标有明显异常改变 ,主要表现在全血高切粘度和全血低切粘度明显升高。随着肝脏病变的进一步发展 ,门静脉血流动力学和血液流变学变化有着明显相关性。【结论】血液流变学的改变在肝硬化门静脉高压症的形成过程中起着重要作用。Objective To explore the changes of portal hemodynamics and hemorrheology in development of experimental liver cirrhosis. Methods The parameters of hemodynamics and hemorrheology were tested in different stages of rats with liver cirrhosis. Results The index of hemorrheology had abnormal changes,especially the high shear viscosity and low shear viscosity of whole blood increased significantly in liver cirrhosis rats.Correlation between portal hemodynamics and hemorrheology was very close when cirrhosis is developing further in rats. Conclusions Hemorrheology might play an important role in the pathogenesis of portal hypertension.

关 键 词：肝硬化 实验性 门静脉 血流支力学 血液流变学 

分 类 号：R575.2[医药卫生—消化系统]