肝细胞肝癌组织SATB1表达及其临床意义的研究  

Expression of SATB1 and its clinic significance in hepatocellular carcinoma tissues

作　　者：彭正奎[1] 杨定华[1] 李湘竑[1] 黄毓[2] 张国强[1] 钟克波[1] 毕民平[1] 李光辉[1] 

机构地区：[1]南方医科大学南方医院肝胆外科,广东广州510515 [2]南方医科大学南方医院检验科,广东广州510515

出　　处：《中华肿瘤防治杂志》2011年第9期697-700,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：广东省基金面上项目(C1030281)

摘　　要：目的:探讨肝细胞肝癌(HCC)组织中SATB1的表达及其临床意义。方法:用RT-PCR方法和蛋白质印迹法检测40例HCC组织及对应的癌旁组织中SATB1的表达,并分析SATB1蛋白的表达程度与患者临床病理参数、术后复发与转移的关系。结果:HCC组织中SATB1蛋白的表达明显高于癌旁组织,P<0.001。癌组织中SATB1蛋白表达的高低与AFP、肿瘤大小、癌栓、病理分化、TNM分级、术后复发转移有关系,P<0.05;与性别、年龄、乙型肝炎表面抗原、丙型肝炎抗体、肿瘤的数目、肝硬化和包膜无关,P>0.05。结论:SATB1蛋白的表达与HCC的复发转移有关,SATB1有望成为HCC复发与转移的一个新的预后指标。OBJECTIVE： To investigate the correlation of AT-rich sequence-binding protein （SATB1） in hepatocellular carcinoma （HCC） and discuss its clinical significance. METHODS： The expression of SATB1 in 40 cases of HCC tissues and its adjacent tissues was detected by RT-PCR and Western blotting. And the relationships between SATB1 protein expression and the clinical pathological parameters, recurrence and metastasis were analyzed. RESULTS： The expression of SATB1 protein in HCC tissues was higher than that in adjacent tissues （P〈0. 001）. The expression of SATB1 protein in HCC tissues was associated with AFP, tumor size,tumor thrombus, histological differentiation, TNM classification, recurrence and metastasis after surgical resection（P〈0.05）. There was no relationship between the expression of SATB1 and gender, age, HbsAg positive, HCV-Ab positive, tumor number, liver cirrhosis, envelope （P 〉 0.05 ）. CONCLUSIONS： SATB1 protein expression may be associated with the recurrence and metastasis of HCC. SATB1 protein expression may potentially use as an indicator for predicting the prognosis in the recurrence and metastasis of HCC.

关 键 词：癌 肝细胞 核基质蛋白质类 RT—PCR 

分 类 号：R735.7[医药卫生—肿瘤]