鼻咽癌两种放射治疗方案的成本效果分析  

Cost-effectiveness analysis of two kinds of radiotherapy for nasopharyngeal carcinoma

作　　者：王仁生[1] 韦波[2] 苏莉[3] 冯启明[2] 曾冬[2] 罗红叶[2] 

机构地区：[1]广西医科大学第一附属医院放疗科,广西南宁530021 [2]广西医科大学公共卫生学院,广西南宁530021 [3]广西壮族自治区疾病预防控制中心,广西南宁530021

出　　处：《中华肿瘤防治杂志》2011年第9期707-709,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：广西科学研究与技术开发计划项目(桂科攻0632007-2F);广西自然科学基金(桂科自0542090);广西卫生厅重点课题(重200527);广西卫生厅自筹课题(Z2007019)

摘　　要：目的:分析常规放疗和调强放疗方案治疗鼻咽癌(NPC)的成本与效果。方法:分别采用常规放疗和调强放疗方案,对546例NPC患者进行放射治疗。计算各组患者的成本、完全缓解率以及成本效果比(C/E)、增量成本效果比(△C/△E)。结果:1)成本:Ⅰ+Ⅱ期、Ⅲ期和Ⅳ期调强组成本显著高于常规组,P均<0.01。2)效果:调强组Ⅰ+Ⅱ期、Ⅲ期和Ⅳ期完全缓解率分别为92.86%、91.67%和76.00%,常规组Ⅰ+Ⅱ期、Ⅲ期和Ⅳ期完全缓解率分别为68.48%、58.05%和50.77%。各期内调强组完全缓解率均显著高于常规组,P均<0.01。3)成本-效果:Ⅰ+Ⅱ期,调强组C/E(600.60)高于常规组(360.80);Ⅲ期,调强组C/E(711.88)高于常规组(442.59);Ⅳ期,调强组C/E(881.66)高于常规组(512.61)。△C/△E(以成本较低的常规组作为参照)分别为Ⅰ+Ⅱ期1 274.16、Ⅲ期1 176.87、Ⅳ期1 624.29。结论:常规放疗方案在费用控制方面占优势,但调强放疗效果远好于常规放疗,建议经济状况允许的患者选择调强放疗方案。OBJECTIVE： To analyze the cost and effect of conventional radiotherapy and intensity-modulated radiotherapy for nasopharyngeal carcinoma. METHODS：Totally 546 patients were treated with conventional radiotherapy and intensity-modulated radiotherapy respectively. The cost, complete response rate, cost-effectiveness ratio （C/ E） and incremental cost effectiveness ratio （AC/AE） of each group were calculated. RESULTS： 1）Cost： The cost of intensity-modulated groups were significantly higher than the conventional group in each period （P〈0.01）. 2）Effect： In Ⅰ ＋ Ⅱ period, the complete remission rate of intensity-modulated group was 92.86%, 91.67% in Ⅲ period, and 76.00% in Ⅳ period, which were significantly higher than the conventional group in each period which were 68.48% in Ⅰ ＋ Ⅱ period, 58.05% in Ⅲ period and 50.77% in Ⅳ period （P〈0.01）. 3）Cost-effectiveness： In Ⅰ ＋ Ⅱ period, the C/E of intensity-modulated group （600.60） was higher than that of the conventional group （360.80）. In m period, the C/E of intensity-modulated group （711.88） was higher than that of the conventional group （442.59）. In IV period, the C/E of intensity-modulated group （881.66） was higher than that of the conventional group （512.61）. And the AC/AE （take the lower cost of conventional group as a reference） was 1 274.16 in Ⅰ ＋ Ⅱ period, 1 176.87 in Ⅲ period, 1 624. 29 in Ⅳ period. CONCLUSIONS： The conventional radiotherapy is cheaper than the intensity-modulated radiotherapy, but the effect of intensity-modulated radiotherapy is better than conventional radiotherapy. It＇s suggested that the intensity-modulated radiotherapy should be preferred if the economic conditions allowed.

关 键 词：鼻咽肿瘤/放射疗法 常规放疗 调强放疗 成本-效果 

分 类 号：R739.63[医药卫生—肿瘤]