亚低温治疗对实验性大鼠脑出血的保护作用研究  

Protective effects of moderate hypothermia after experimetal cerebral hemorrhage in rats.

作　　者：牛国忠[1] 顾小林[1] 华洁[1] 卢国跃[1] 金石[1] 

机构地区：[1]杭州市第一人民医院神经科,310006

出　　处：《中华神经外科杂志》1999年第5期288-290,共3页Chinese Journal of Neurosurgery

基　　金：浙江省卫生厅资助课题

摘　　要：目的　本文观察了３２ ℃亚低温对脑出血大鼠脑 Ｎａ＋ 、 Ｋ＋ 、水含量及超微结构的影响。方法　６６ 只大鼠随机分成三组： （１） 假手术对照组； （２） 常温脑出血组； （３） 亚低温脑出血组。结果常温出血组水、 Ｎａ＋ 含量随时间而增加， 而 Ｋ＋ 含量减少； 亚低温组水、 Ｎａ＋ 含量比常温组低， 而 Ｋ＋含量增加。超微结构显示亚低温组脑超微结构损害较常温组轻。结论　亚低温治疗对脑出血后脑水肿， 脑细胞结构有保护作用。Objective To observe the effects of moderate hypothermia on Na +、K +、water and ultrastructural changes after cerebral hemorrhage in rats brain. Methods Sixty six rats were divided into three Group:(1)sham operated group; (2)normothermic groups(37℃); (3)hypothermic group:(32℃).Results In the normothemic group, Na + and water is increased. and K + decreased significantly with the time. In the hypothermic group Na + and water is lower and K + is higher than those of normothermic group, Ultrastructure is less injury than that of normothermic group. Conclusion Moderate hypothemia has a protective effect on cerebral edema and ultrastructures injury after cerebral hemorrhage.

关 键 词：脑出血 亚低温治疗 实验研究 

分 类 号：R743.340.5[医药卫生—神经病学与精神病学] R454.5[医药卫生—临床医学]