血小板源性生长因子B在非小细胞肺癌中的表达及其与微血管密度的关系  

Expressions of PDGF-B in non-small cell lung cancer and its relationship with microvessel density

作　　者：沈令广[1] 黄庆功[2] 李俭银[1] 徐鹏[1] 王丹云[1] 王宗明[1] 杨长征[1] 

机构地区：[1]山东大学附属济南市中心医院胸外科,山东济南250013 [2]山东省胜利石油管理局胜北医院外科,山东东营257064

出　　处：《中国现代医学杂志》2011年第16期1841-1844,共4页China Journal of Modern Medicine

摘　　要：目的探讨非小细胞肺癌(NSCLC)组织中血小板源性生长因子B(PDGF-B)的表达及微血管密度(MVD)在NSCLC血管生成及生物学行为的关系。方法用免疫组织化学方法检测65例非小细胞肺癌和18例正常肺组织中PDGF-B表达及MVD。结果 NSCLC组织中PDGF-B的阳性表达率为58.5%,MVD值为(34.66±8.91)。两者均显著高于正常肺组织(P<0.05);PDGF-B的表达与癌组织的分化程度、淋巴结转移及临床分期显著相关(P<0.01);MVD值与癌组织的大小、分化程度、淋巴结转移及临床分期显著相关(P<0.05或P<0.01);NSCLC组织中,PDGF-B与MVD的表达呈正相关(R=0.488,P<0.05)。结论 PDGF-B是NSCLC血管生成的正性调节因子,说明其可能在促进血管生成机制中起一定作用,对肺癌的生长、侵袭及转移中起重要作用。[Objective] To investigate the expression of platelet-derived growth factor B（PDGF-B） and microvessel density（MVD） with the angiogenesis and the biological behaviour characteristics in non-small cell lung cancer（NSCLC）.[Methods] The expression of PDGF-B and microvessel density（MVD） in 65 cases of NSCLC and 18 normal lung tissue were examined by immunohistochemical method.[Results] The positive expression of PDGF-B（58.5%）,MVD（43.13±15.40） was significantly higher than those in normal tissues（P 0.05）.The PDGF-B and MVD expression in NSCLC was significantly associated with tumor size,differentiation degree,lymph node metastasis and clinical stage（P 0.05 or P 0.01）.There was a positive correlation between expression of PDGF-B and MVD（R =0.488,P 0.05）.[Conclusions] PDGF-B is an positive angiogenesis factor and plays an important role in the development and metastasis of NSCLC.

关 键 词：非小细胞肺癌 血小板源性生长因子B 微血管密度 免疫组化学 

分 类 号：R734.2[医药卫生—肿瘤]