FcγR基因型与早发性牙周炎易感性的研究  

Relevance of FcγR polymorphism to the susceptibility of early-onset periodontitis

作　　者：伏雅莉[1] 曹采方[1] 王申五 

机构地区：[1]北京医科大学口腔医学院,100081 [2]人民医院中心实验室

出　　处：《中华口腔医学杂志》1999年第6期364-366,共3页Chinese Journal of Stomatology

摘　　要：目的　探讨FcγR基因多态性与早发性牙周炎 (early onsetperiodontitis ,EOP)易感性的关系。方法　提取 3 3例EOP和 2 7名健康对照者的静脉血白细胞DNA ,分别用PCR +BstUI酶切和PCR +测序检测FcγRIIA和FcγRIIIB的基因型 ,比较各基因型检出率的差别。结果　FcγRIIA基因型在两组间的分布无差别 ,FcγRIIIBNA1/NA1的检出率高于健康对照组。结论　FcγRIIIBNA1/NA1基因型可能是EOP的遗传易感因素。Objective To investigate the polymorphism of the FcγR genotype and its association with the susceptibility of early onset periodontitis (EOP) Methods DNA of the white blood cells from 33 subjects with EOP and 27 healthy controls was extracted Genotypes of the FcγRIIA and FcγRIIIB were determined by PCR followed by BstUI restriction endonuclease digestion and DNA sequencing, respectively Then compared the differences in distribution of each genotype Results No statistical difference in distribution of FcγRIIA was observed between patients and controls However, a significant over representation of the FcγRIIIB NA1/NA1 was found in EOP Conclusion These results suggest that the FcγRIIIB NA1/NA1 may be a risk indicator for the susceptibility of the EOP

关 键 词：牙周炎 IgG受体 基因型 疾病易感性 

分 类 号：R781.42[医药卫生—口腔医学]