FXYD蛋白与Na,K-ATP酶  

FXYD proteins and Na,K-ATPase

作　　者：詹阳[1,2] 朱力[1,2] 

机构地区：[1]首都医科大学附属北京妇产医院 [2]北京妇幼保健院病理科,北京100006

出　　处：《国际病理科学与临床杂志》2011年第3期264-268,共5页Journal of International Pathology and Clinical Medicine

摘　　要：Na,K-ATP酶最初被描述为一种能量转换的离子泵。近期研究显示Na,K-ATP酶有更多的生物学功能,特别是它参与一些信号转导通路,导致了一些生长相关基因表达的改变,最终影响细胞生长。FXYD蛋白家族成员是小分子膜蛋白,因其都有FXYD氨基酸序列而得名,7个家族成员具有与Na,K-ATP酶相关的组织或同功酶特异性,可调节其运输特性。Na,K-ATPase is a first reported ion pump for energy transduction.Recent studies suggest that Na,K-ATPase has many biological functions.Especially,it interplays with several signal pathways and results in changes in a number of growth-related genes expression,through which to regulate cell growth.The family of FXYD are proteins with small membrane characterized by an FXYD motif.Recent evidence suggests that seven FXYD proteins correlate with Na,K-ATPase and they can modulate transport properties of Na,K-ATPase in a tissue-and isoform-specific way.

关 键 词：FXYD蛋白 NA K-ATP酶 调节 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]