survivin在非小细胞肺癌中的表达及其与细胞凋亡的关系  

Expression of Survivin and Its Relationship with Apoptosis in Non-small Cell Lung Cancer

作　　者：黄仲[1] 杨志雄[1] 廖思海[1] 李姝君[1] 苏文媚[1] 

机构地区：[1]广东医学院附属医院肿瘤中心一区,广东湛江524001

出　　处：《肿瘤预防与治疗》2011年第4期142-145,共4页Journal of Cancer Control And Treatment

基　　金：广东省社会发展领域科技计划项目(编号:2008B030301018)

摘　　要：目的:检测非小细胞肺癌(NSCLC)中suFvivin表达水平及凋亡指数(AI)大小,探讨其临床病理意义、在肺癌发生和进展中的作用以及二者可能存在的相关性。方法:应用免疫组织化学法检测108例NSCLC,60例癌旁肺组织survivin表达情况,原位末端标记法(TUNEL)检测AI大小。结果:survivin在NSCLC中表达高于癌旁肺组织(P<0.05),NSCLC中AI小于癌旁肺组织(P<0.05),survivin表达及AI均与肿瘤组织的分化程度、TNM分期及淋巴结转移有关(P<0.05),sirvivin表达与AI呈负相关(P<0.05)。结论:细胞凋亡水平异常可能在肺癌发生发展中起重要作用,survivin可能通过抑制细胞凋亡参与了肺癌的发生、发展。Objective： To study the expression of survivin protein in non-small cell lung cancer（NSCLC） and its relationship with the apoptosis index（AI）. To investigate their relationships with the biological behavior, occurrence and progress of lung cancer. Methods： Immunohistochemical method was used to detect the expression of survivin in NSCLC and adjacent tumor tissues. The AI was detected by Terminal-deoxynucleoitidy Transferase Mediated Nick End Labeling （TUNEL） method. Results： The expression of survivin in NSCLC was significantly higher than that in adjacent tumor tissues （P 〈 0.05）. AI of lung cancer cells was lower than that of adjacent tumor tissues （ P 〈 0.05）. Survivin and AI were associated with histological differentiation, clinical stage and lymph node metastasis of tumor（P 〈 0.05）. A correlation coefficient test showed an negative correlation between the AI of tumor cells and the level of survivin expression in NSCLC （P 〈 0.05 ）. Conclusion： Apoptotic suppression may play an important role in the oncogenesis and development of NSCLC. Survivin may participate in the pristine genesis and development of NSCLC by inhibiting the apoptosis.

关 键 词：非小细胞肺癌 SURVIVIN 凋亡 

分 类 号：R734.2[医药卫生—肿瘤]